2-(4-bromophenyl)-1-(4-chlorophenyl)-3-(2,2,2-trifluoro-N-(4-methoxyphenyl)acetamido)benzo[d]pyrazolo[1,2-a][1,2,3]triazol-4-ium-5-ide | 627088-30-6

• 英文名称: 2-(4-bromophenyl)-1-(4-chlorophenyl)-3-(2,2,2-trifluoro-N-(4-methoxyphenyl)acetamido)benzo[d]pyrazolo[1,2-a][1,2,3]triazol-4-ium-5-ide
• CAS: 627088-30-6
• 化学式: C₃₀H₁₉BrClF₃N₄O₂
• 分子量: 639.859
• InChiKey: VMIUGAOQSZZDQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  2-(4-bromophenyl)-1-(4-chlorophenyl)-3-(2,2,2-trifluoro-N-(4-methoxyphenyl)acetamido)benzo[d]pyrazolo[1,2-a][1,2,3]triazol-4-ium-5-ide 以 甲醇 为溶剂， 以82%的产率得到
  参考文献：
  名称：

  A novel synthesis of 4,5-diaryl-6-arylamino-2,3-benzo-1,3a,6a-triazapentalenes

  摘要：

  Treatment of N-alkyl- and N-aryl-imines of 2,3-diaryl- and 2-alkyl-3-aryl-3-(benzotriazol-1-yl)propenals with trifluoroacetic anhydride in THF at room temperature gave 5-alkyl-4-aryl-6-[N-alkyl (and aryl)-N-trifluoroacetyl]amino-2,3-benzo-1,3a,6a-triazapentalenes in moderate to good yields. On heating triazapentalenes having R-2 = aryl in MeOH at reflux, detrifluoroacetylation of triazapentalene occurred to give title compounds in good yields. However, the same treatment of triazapentalenes having R-2=alkyl did not give the corresponding detrifluoroacetylation product. The title compounds and 5-alkyl-4-aryl-6-(N-alkyl-N-trifluoroacetyl)amino-2,3-benzo-1,3a,6a-triazapentalenes were found to be good precursors for the synthesis of 1-(o-aminophenyl)-3-arylamino-4-alkyl (and aryl)-5-arylpyrazoles and 1-(o-aminophenyl)-3-(N-alkyl-N-trifluoroacetyl)amino-4-alkyl (and aryl)-5-arylpyrazoles, respectively. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.08.012
• 作为产物：
  描述：

  (E)-3-Benzotriazol-1-yl-2-(4-bromo-phenyl)-3-(4-chloro-phenyl)-prop-2-en-1-ol 在 草酰氯 、 二甲基亚砜 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 14.0h， 生成 2-(4-bromophenyl)-1-(4-chlorophenyl)-3-(2,2,2-trifluoro-N-(4-methoxyphenyl)acetamido)benzo[d]pyrazolo[1,2-a][1,2,3]triazol-4-ium-5-ide
  参考文献：
  名称：

  A novel synthesis of 4,5-diaryl-6-arylamino-2,3-benzo-1,3a,6a-triazapentalenes

  摘要：

  Treatment of N-alkyl- and N-aryl-imines of 2,3-diaryl- and 2-alkyl-3-aryl-3-(benzotriazol-1-yl)propenals with trifluoroacetic anhydride in THF at room temperature gave 5-alkyl-4-aryl-6-[N-alkyl (and aryl)-N-trifluoroacetyl]amino-2,3-benzo-1,3a,6a-triazapentalenes in moderate to good yields. On heating triazapentalenes having R-2 = aryl in MeOH at reflux, detrifluoroacetylation of triazapentalene occurred to give title compounds in good yields. However, the same treatment of triazapentalenes having R-2=alkyl did not give the corresponding detrifluoroacetylation product. The title compounds and 5-alkyl-4-aryl-6-(N-alkyl-N-trifluoroacetyl)amino-2,3-benzo-1,3a,6a-triazapentalenes were found to be good precursors for the synthesis of 1-(o-aminophenyl)-3-arylamino-4-alkyl (and aryl)-5-arylpyrazoles and 1-(o-aminophenyl)-3-(N-alkyl-N-trifluoroacetyl)amino-4-alkyl (and aryl)-5-arylpyrazoles, respectively. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.08.012