(S(p))-1-Ph2P-2-(3,5-(CH3)2C6H3)2PCH2-3-CH3-Fc | 925419-17-6

• 英文名称: (S(p))-1-Ph2P-2-(3,5-(CH3)2C6H3)2PCH2-3-CH3-Fc
• 英文别名: (Sp)-1-diphenylphosphino-2-bis(3,5-dimethylphenyl)phosphinomethyl-3-methylferrocene
• CAS: 925419-17-6
• 化学式: C₄₀H₄₀FeP₂
• 分子量: 638.552
• InChiKey: KTISCBXIMQDZIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  双(乙腈)氯化钯(II) 、 (S(p))-1-Ph2P-2-(3,5-(CH3)2C6H3)2PCH2-3-CH3-Fc 以 苯 为溶剂， 以56%的产率得到[PdCl2((S(p))-1-Ph2P-2-(3,5-(CH3)2C6H3)2PCH2-3-CH3-Fc)]
  参考文献：
  名称：

  Synthesis and Use in Asymmetric Hydrogenations of Solely Planar Chiral 1,2-Disubstituted and 1,2,3-Trisubstituted Ferrocenyl Diphosphines:  A Comparative Study

  摘要：

  A total of 12 enantiopure 1,2-disubstituted and 1,2,3-trisubstituted ferrocenyl diphosphines [1-Ph2P-2-R2PCH2-3-R'-Fc, R = Cy, t-Bu, 3,5-(CH3)(2)C6H3), R' = H, CH3, Ph, 3,5-(CH3)(2)C6H3)] have been synthesized, characterized, and tested in asymmetric rhodium- and ruthenium-catalyzed hydrogenations of four alkenes and two ketones. The performance of these ferrocene derivatives in catalytic hydrogenations was compared to those of catalysts based on Josiphos, PPF-t-Bu-2, and Xyliphos [1-Ph2P-2-R2P(CH3)CH-Fc, R = Cy, t-Bu, 3,5-(CH3)(2)C6H3)]. Dichloro palladium(II) complexes of Xyliphos and its analogues lacking the stereogenic center were synthesized as model compounds, and their molecular structures were studied in solution and, for four complexes, in the solid state. In hydrogenation reactions the replacement of Xyliphos as the catalyst ligand with its analogues lacking the stereogenic center leads to changes in product configurations or significant increases or decreases in ee values.

  DOI：

  10.1021/om700405a
• 作为产物：
  描述：

  (1R,2S,S(p))-[(C5H5)Fe(C5H2(CH3)(P(C6H5)2)CH2N(CH3)CH(CH3)CH(C6H5)OCH3)] 、 双(3,5-二甲苯基)磷 以 溶剂黄146 、 甲苯 为溶剂， 反应 16.0h， 以63%的产率得到(S(p))-1-Ph2P-2-(3,5-(CH3)2C6H3)2PCH2-3-CH3-Fc
  参考文献：
  名称：

  WO2007/17522

  摘要：

  公开号：
• 作为试剂：
  描述：

  N-(2-ethyl-6-methylphenyl)-N-(1'-methoxymethyl)-ethylidene-amine 在 bis(1,5-cyclooctadiene)diiridium(I) dichloride 、 (S(p))-1-Ph2P-2-(3,5-(CH3)2C6H3)2PCH2-3-CH3-Fc 氢气 、 四丁基碘化铵 作用下， 以 溶剂黄146 为溶剂， 反应 2.5h， 以72.2%的产率得到
  参考文献：
  名称：

  WO2007/17522

  摘要：

  公开号：