cis-[RuCl₂(triphenylphospine)₂(4,4′-methylbipyridine)] | 366452-47-3

• 英文名称: cis-[RuCl₂(triphenylphospine)₂(4,4′-methylbipyridine)]
• 英文别名: cis-[RuCl₂(PPh₃)₂(Me-bipy)]；cis-[RuCl2(PPh3)2(4,4'-dimethyl-2,2'-bipyridine)]；[Ru(4,4'-dimethyl-2,2'-bipyridine)(PPh3)2Cl2]；RuCl2(PPh3)2(4,4'-dimethyl-2,2'-bipyridine)；Ru(4,4'-dimethyl-2,2'-bipyridyl)(PPh3)2Cl2；Ru(Me2bipy)(PPh3)2Cl2
• CAS: 366452-47-3
• 化学式: C₄₈H₄₂Cl₂N₂P₂Ru
• 分子量: 880.798
• InChiKey: QADYYPWGLNJBER-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1,3-双(二苯基膦)丙烷 、 cis-[RuCl₂(triphenylphospine)₂(4,4′-methylbipyridine)] 以 二氯甲烷 、 苯 为溶剂， 反应 96.0h， 以90%的产率得到cis-[RuCl₂(1,4-bis(diphenylphosphino)butane)(4,4′-dimethyl-2,2′-bipyridine)]
  参考文献：
  名称：

  New ruthenium(II)/phosphines/diimines complexes: Promising antitumor (human breast cancer) and Mycobacterium tuberculosis fighting agents

  摘要：

  The synthesis and characterization of ruthenium compounds of the type [RuCl2(P)(2)(NN)] [(P)(2) = (PPh3)(2),dppb = 1,4-bis(diphenylphosphino)butano; dppp = 1,3-bis(diphenylphosphino)propane; NN = 5,5'-dimethyl-2,2'dipyridyl (5,5'-mebipy) or 4,4'-dimethyl-2,2'dipyridyl (4,4'-mebipy)] are described. The complexes were characterized using elemental analysis, UVVis and infrared spectroscopies, cyclic voltammetry, and X-ray crystallography. In vitro evaluation of the complexes, using the MTT methodology, revealed their cytotoxic activities in a range of 5.415.7 mu M against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The in vitro antimycobacterial activities of the complexes had their Minimum Inhibitory Concentration (MIC) for MTB cell growth measured, by the REMA method. The MICs for these complexes were found to be between 12.5 and 25.0 mu g/mL. The results are comparable with the second line drug cycloserine (MIC = 12.550.0 mu g/mL), commonly used in the treatment of TB. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2013.01.004
• 作为产物：
  描述：

  tris(triphenylphosphine)ruthenium(II) chloride 、 4,4'-二甲基-2,2'-联吡啶 以 二氯甲烷 为溶剂， 反应 0.5h， 以Ca. 78 mg的产率得到cis-[RuCl₂(triphenylphospine)₂(4,4′-methylbipyridine)]
  参考文献：
  名称：

  新型钌/ lapachol复合物的抗寄生虫活性

  摘要：

  本研究描述了新型二亚胺/（2,2'-联吡啶（bipy），1,10-菲咯啉（phen），4,4'-甲基联吡啶（Me-bipy）和4含有拉帕胆酚（Lap，2-羟基-3-（3-33甲基-2-丁烯基）-1，4-萘醌）的4，4′-甲氧基联吡啶（MeO-联吡啶）/膦/钌（II）配合物作为二齿配体。 [Ru（Lap）（PPh 3）2（bipy）] PF 6（1），[Ru（Lap）（PPh 3）2（Me-bipy）] PF 6（2），[Ru（Lap）（PPh）3）2（MeO-bipy）] PF 6 （3）和[Ru（Lap）（PPh 3）2[phen]] PF 6（4）络合物PPh 3  =三苯基膦，是由顺- [RuCl 2（PPh 3）2（X-bipy）]或顺- [RuCl 2（PPh 3）2（ phen）]，与lapachol。从mer- [RuCl 3（dppb）（H 2 O）]络合物合成[RuCl 2（Lap）（dppb）]

  DOI：

  10.1016/j.jinorgbio.2014.03.009

文献信息

• Observation of vinylidene emission in mixed phosphine/diimine complexes of Ru(II) at room temperature in solution
  作者：André L. Bogado、Rose M. Carlos、Cristina Daólio、Antonio G. Ferreira、Miguel G. Neumann、Frank Rominger、Sergio P. Machado、Juliana P. da Silva、Márcio P. de Araujo、Alzir A. Batista

  DOI：10.1016/j.jorganchem.2011.09.017

  日期：2012.1

  The mixed ruthenium(II) complexes trans-[RuCl2(PPh3)2(bipy)] (1), trans-[RuCl2(PPh3)2(Me2bipy)](2), cis-[RuCl2(dcype)(bipy)](3), cis-[RuCl2(dcype)(Me2bipy)](4) (PPh3 = triphenylphosphine, dcype = 1,2-bis(dicyclohexylphosphino)ethane, bipy = 2,2′-bipyridine, Me2bipy = 4,4′-dimethyl-2,2′-bipyridine) were used as precursors to synthesize the associated vinylidene complexes. The complexes [RuCl(CCHPh)(PPh3)2(bipy)]PF6

  混合钌（II）配合物反式-[RuCl 2（PPh 3）2（bipy）]（1），反式-[RuCl 2（PPh 3）2（Me 2 bipy）]（2），顺式-[RuCl 2（dcype）（bipy）]（3），顺式-[RuCl 2（dcype）（Me 2 bipy）]（4）（PPh 3  =三苯基膦，dcype = 1,2-双（二环己基膦基）乙烷，bipy = 2， 2′-联吡啶，Me 2联＝ 4，4′-二甲基-2，2′-联吡啶被用作前体来合成相关的亚乙烯基络合物。络合物[RuCl（C CHPh）（PPh3）2（bipy）] PF 6（5），[RuCl（C CHPh）（PPh 3）2（Me 2 bipy）] PF 6（6），[RuCl（C CHPh）（dcype）（bipy）] PF参照图6（7），对[RuCl（C CHPh）（dcype）（bipy）] PF 6（8）进行了表征，并检查了它们的光
• Ruthenium Phosphine/Diimine Complexes:  Syntheses, Characterization, Reactivity with Carbon Monoxide, and Catalytic Hydrogenation of Ketones
  作者：Márcio P. de Araujo、Alberthmeiry T. de Figueiredo、André L. Bogado、Gustavo Von Poelhsitz、Javier Ellena、Eduardo E. Castellano、Claudio L. Donnici、João V. Comasseto、Alzir A. Batista

  DOI：10.1021/om050182b

  日期：2005.12.1

  The cis-[RuCl2(PPh3)(2)(N-N)] (N-N = bipy (1), Me-bipy (2), phen (3), and bathophen (4)) complexes were used to synthesize five new electron-rich phosphine-containing complexes cis- [RuCl2(dcype)(N-N)] (N-N = bipy (1a), Me-bipy (2a), phen (3a), and bathophen (4a)) and cis- [RuCl2(PEt3)(2)(bipy)] (1c) by phosphine exchange. These complexes were obtained and characterized by NMR (P-31H-1}, H-1), cyclic voltammetry, and elemental analysis. Electrochemical studies of these complexes reveal a single reduction process (Ru-III/Ru-II). These complexes are more easily oxidized than their analogues cis-[RuCl2(dppb)(N-N)]. The reactivity of complexes cis-[RuCl2(dcype)(N-N)] with carbon monoxide was tested, and dissociation of one chloride was observed, leading to the formation of four new cationic species with general formula [RuCl(CO)(dcype)(N-N)](PF6) (bipy (1b), Me-bipy (2b), phen (3b), and bathophen (4b)). The complexes described here and elsewhere with general formulas cis-[RuCl2(P-P)(N-N)], [RuCl(CO)(dcype)(N-N)] (PF6) and cis-[RuCl2(P)(2)(N-N)] were used as precatalysts in the transfer hydrogenation of functionalized aryl-ketones, and most of them were active. X-ray structures of cis- [RuCl2(PEt3)(2)(bipy)] (1c) and [RuCl(CO)(dcype)(bipy)](PF6) (1b) will be presented.
• Electrochemical and spectroscopic studies on RuCl2(PPh3)2(N)2 and RuCl2(PPh3)2(N–N) complexes (N=pyridine derivatives and N–N=phenanthroline or bipyridine derivatives). X-ray structure of RuCl2(PPh3)2(phen)
  作者：Alzir A Batista、Marcelo O Santiago、Claudio L Donnici、Icaro S Moreira、Peter C Healy、Susan J Berners-Price、Salete L Queiroz

  DOI：10.1016/s0277-5387(01)00744-6

  日期：2001.7

  A series of RUCl2(PPh3)(2)(N)(2) and RUCl2(pPh(3))(2)(N - N) complexes were synthesized from RuCl2(PPh3)(3), (N)(2) = pyridine (py), 4-(N,N-dirnethylamino)pyridine (4-dmNpy), 4-tert-butylpyridine (4-' Bu-py), 4-methylpyridine (4-Mepy), 4-vinylpyridine (4-Vpy), 4-phenylpyridine (4-Phpy), isonicotinamide (4-CONH(2)py). 4-cyanopyridine (4-CNpy) N-N = 1,10-phenanthroline (phen), 2,2 ' -bipyridine (bipy), 2,2 ' -bipyridine-4,4 ' -dimethoxy (MeO-bipy), 2,2 ' -bipyridine-4,4 ' -dimethyl (Me-bipy), 2,2 ' -bipyridine-4,4 ' -dithiomethyl (MeS-bipy), 2,2 ' -bipyridine-4,4 ' -dichloro (Cl-bipy) and 2,2 ' -bipyridine-4,4 ' -dinitro (NO2-bipy). The complexes were characterized by elemental analysis, cyclic voltammetry and U-V-Vis, NMR and IR spectroscopies. The structure of the RUCl2(PPh3)(2)(phen) was established by single crystal X-ray crystallography. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Adams, Christopher J., Journal of the Chemical Society. Dalton Transactions (2001), 2002, # 7, p. 1545 - 1550
  作者：Adams, Christopher J.

  DOI：——

  日期：——
• Diimine−Acetylide Compounds of Ruthenium:  The Structural and Spectroscopic Effects of Oxidation
  作者：Christopher J. Adams、Simon J. A. Pope

  DOI：10.1021/ic035181v

  日期：2004.5.1

  The reaction of Ru(Me(2)bipy)(PPh3)(2)Cl-2 1 with terminal alkynes HCCR in the presence of TIPF6 leads to the formation of the vinylidene compounds [Ru(Me(2)bipy)(PPh3)(2)Cl(=C=CHR)][PF6] (2) (2a, R = Bu-t; 2b, R = p-C6H4-Me; 2c, R = Ph). These compounds decompose in oxygenated solution to form the carbonyl compound [Ru(Me(2)bipy)(PPh3)(2)Cl(CO)][PF6] (3), and may be deprotonated by K2CO3 to give the ruthenium(II) terminal acetylide compounds Ru(Me(2)bipy)(PPh3)(2)Cl(CdropC-R) (4) (4a, R = Bu-t; 4b, R = p-C6H4-Me; 4c, R = Ph). Cyclic voltammetry shows that 2a-c may also be reductively dehydrogenated to form 4a-c. 4a-c are readily oxidized to their ruthenium(III) analogues [4a](+)-[4c](+), and the changes seen in their UV/visible spectra upon performing this oxidation are analyzed. These show that whereas the UV/visible spectra of 4a-c show MLCT bands from the ruthenium atom to the bipyridyl ligand, those of [4a](+)-[4c](+) contain LMCT bands originating on the acetylide ligands. This is in agreement with the IR and ESR spectra of [4a](+)-[4c](+). The X-ray crystal structures of the redox pair 4a and [4a][PF6] have been determined, allowing the bonding within the metal-acetylide unit to be analyzed, and an attempt is made to determine Lever electrochemical parameters (E-L) for the vinylidene and acetylide ligands seen herein. Room temperature luminescence measurements on 4a-c show that the compounds are not strongly emissive.