2-iodoquindoline | 874212-47-2

• 英文名称: 2-iodoquindoline
• 英文别名: 2-Iodo-10h-indolo[3,2-b]quinoline
• CAS: 874212-47-2
• 化学式: C₁₅H₉IN₂
• 分子量: 344.154
• InChiKey: GFPJAKCEFDRJHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-iodoquindoline 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 、 环丁砜 为溶剂， 生成
  参考文献：
  名称：

  Substituted Indoloquinolines as New Antifungal Agents

  摘要：

  Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine. Comparison of MICs of a number of these analogues with standard antifungal agents, shows them to be comparable to Amphotericin B and Ketoconazole. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00401-1
• 作为产物：
  描述：

  邻硝基苯乙酮 在 盐酸 、 亚磷酸三乙酯 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 4.08h， 生成 2-iodoquindoline
  参考文献：
  名称：

  Thermal cyclization of 3-arylamino-3-(2-nitrophenyl)-propenal Schiff base hydrochlorides followed by triethyl phosphite mediated deoxygenation: a facile synthesis of quindolines

  摘要：

  A simple and useful method for the synthesis of various 2-substituted quindolines starting from 2-nitroacetophenone is described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.007