[Au(κ2-C,N-C6H4(PPh2=N(C6H5))-2)Cl2] | 933788-24-0

• 英文名称: [Au(κ2-C,N-C6H4(PPh2=N(C6H5))-2)Cl2]
• 英文别名: [Au(κ2-C,N-C6H4(PPh2=N(C6H5)-2)Cl2]；[(C6H4P(Ph2)N(Ph))gold(III)(dichloride)]；[2-Cl2AuC6H4)Ph2P=NPh]；(2-Cl2AuC6H4)Ph2P=NPh
• CAS: 933788-24-0
• 化学式: C₂₄H₁₉AuCl₂NP
• 分子量: 620.268
• InChiKey: NQOHCLYLWLLQPJ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  [Au(κ2-C,N-C6H4(PPh2=N(C6H5))-2)Cl2] 、 硫代水杨酸 在 (CH₃)3N 作用下， 以 甲醇 为溶剂， 以88%的产率得到
  参考文献：
  名称：

  Synthesis and reactivity of gold(III) complexes containing cycloaurated iminophosphorane ligands

  摘要：

  Transmetallation reactions of ortho-mercurated iminophosphoranes (2-ClHgC6H4)Ph2P=NR with [AuCl4] gives new cycloaurated iminophosphorane complexes of gold(III) (2-Cl2AuC6H4)Ph2P=NR [R = (R, S)- or (S)-CHMePh, p-C6H4F, Bu-t], characterised by NMR and IR spectroscopies, ESI mass spectrometry and an X-ray structure determination on the chiral derivative R = (S)-CHMePh. The chloride ligands of these complexes can be readily replaced by the chelating ligands thiosalicylate and catecholate; the resulting derivatives show markedly higher anti-tumour activity versus P388 murine leukaemia cells compared to the parent chloride complexes. Reaction of (2-Cl2AuC6H4)Ph2P=NPh with PPh3 results in displacement of a chloride ligand giving the cationic complex [(2-Cl(PPh3)AuC6H4)Ph2P=NPh](+), indicating that the P=N donor is strongly bonded to the gold centre. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2009.04.024
• 作为产物：
  描述：

  四苯基氨化膦 在 PhBr 、 BuLi 、 Me₄NCl 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 、 乙腈 为溶剂， 生成 [Au(κ2-C,N-C6H4(PPh2=N(C6H5))-2)Cl2]
  参考文献：
  名称：

  Orthomercurated and cycloaurated derivatives of the iminophosphorane Ph3PNPh

  摘要：

  Ortho-lithiation of Ph-3=NPh followed by reaction with HgCl2 gave good yields of [Hg{C6H4(PPh2=NPh)-2}Cl], 3, which was characterised spectroscopically and by an X-ray crystal structure determination. This is an isomer of the product of direct mercuration of Ph3P=NPh which occurs on the N-bonded phenyl ring [J. Vicente, J.A. Abad, R. Clemente, J. Lopez-Serrano, M.C. Ramirez de Arellano, P.G. Jones, D. Bautista, Organometallics, 22 (2003) 4248]. Transmetallation of 3 with [AuCl4](-) gave the corresponding cycloaurated complex [Au{kappa(2)-C,N-C6H4(PPh2=NPh)-2}Cl-2] with a five-membered metallocyclic ring incorporating four different elements. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.02.009

文献信息

• Synthesis of Apoptosis-Inducing Iminophosphorane Organogold(III) Complexes and Study of Their Interactions with Biomolecular Targets
  作者：Neha Shaik、Alberto Martínez、Idline Augustin、Hugh Giovinazzo、Armando Varela-Ramírez、Mercedes Sanaú、Renato J. Aguilera、María Contel

  DOI：10.1021/ic801925k

  日期：2009.2.16

  (and oxidation state) of the new organogold complexes in solvents like dimethyl sulfoxide and water. Compounds with dithiocarbamato ligands and water-soluble phosphines of the general type [Auκ2-C,N−C6H4(PPh2═N(C6H5)-2}(S2CN-R2)]PF6 (R = Me 2; Bz 3) and [Auκ2-C,N−C6H4(PPh2═N(C6H5)-2}(PR3)nCl]PF6 (PR3 = PCp(m-C6H4−SO3Na)2} n = 1 4, n = 2 TPA 1,3,5-triaza-7-phosphaadamantane} 5) have been synthesized

  含有“钳状”亚氨基正膦配体（2-C 6 H 4 -PPh 2 = NPh）的新型稳定阳离子有机金（III）配合物已通过先前描述的 [Auκ 2 -C, NC 6 H 4 (PPh 2 = N(C 6 H 5 )-2}Cl 2 ] 1以及钠盐或银盐和适当配体的组合。PR 3 中P原子的存在片段已被用作“光谱标记”来研究新的有机金配合物在二甲基亚砜和水等溶剂中的体外稳定性（和氧化态）。具有二硫代氨基甲酸根配体和通用型水溶性膦的化合物[Auκ 2 -C,N-C 6 H 4 (PPh 2 = N(C 6 H 5 )-2}(S 2 CN-R 2 )] PF 6 (R = Me 2 ; Bz 3 ) 和 [Auκ 2 -C,N−C 6 H 4 (PPh 2 = N(C 6 H 5 )-2}(PR 3 )n Cl]PF 6 (PR 3 = PCp( m -C 6 H 4 -SO 3 Na) 2 }
• Organogold(III) Iminophosphorane Complexes as Efficient Catalysts in the Addition of 2-Methylfuran and Electron-Rich Arenes to Methyl Vinyl Ketone
  作者：David Aguilar、María Contel、Rafael Navarro、Esteban P. Urriolabeitia

  DOI：10.1021/om700453s

  日期：2007.8.1

  14) have been found to be the more effective in both the presence and absence of silver salts. With acid-sensitive electron-rich arenes the catalytic activity of these cycloaurated complexes outperformed that of the AuCl3 salt. The synthesis and characterization of new iminophosphorane coordination and organogold(III) compounds are provided along with the results for the catalytic studies.

  在2-甲基呋喃和一些富电子芳烃与甲基乙烯基酮的加成反应中，已评估了含有C，N-钳位配体的环化化合物作为预催化剂。在银盐存在下，所有络合物均显示出与Au（I）络合物相当的催化活性。含有膦亚胺配体（R的化合物3 P NR'）为C，N-骨架如[金κ 2 -C，NC 6 H ^ 4（PPH 2 Ñ（C 6 H ^ 4 X）-2}氯2 ]（X = H，13； X = Me，14已经发现，在存在和不存在银盐的情况下，）都更有效。使用酸敏感的富电子芳烃，这些环链配合物的催化活性优于AuCl 3盐。提供了新的亚氨基正膦配位化合物和有机金（III）化合物的合成和表征，以及用于催化研究的结果。
• Five-coordinate gold(III) complexes of the Kläui ligands [(η5-C5H5)Co{P(O)(OR)2}3]− (R=Me, Et)
  作者：Kelly J. Kilpin、William Henderson、Brian K. Nicholson

  DOI：10.1016/j.ica.2009.08.032

  日期：2009.11

  The reactions of cycloaurated gold(III) dichloride complexes [LAuCl2] (L = 2-C6H4CH2NMe2 or 2-C6H4PPh2=NPh) with monoanionic tripodal oxygen donor Klaui ligands [(eta(5)-C5H5)CoP(O)(OR)(2)}(3)](-) (R = Me or Et) results in the formation of cationic gold(III) salts [LAuOP(OR)(2)}(3)Co(eta(5)-C5H5)](+). An X-ray structure determination on [(2-C6H4PPh2=NPh)AuOP(OR)(2)}(3)Co(eta(5)-C5H5)]BF4 shows that the Klaui ligand coordinates strongly to the gold through two oxygen atoms, and weakly through the third, giving the gold(III) a distorted square pyramidal geometry. This is the first structurally characterised example of this geometry for gold(III) with ligands other than those containing rigid bipyridine or phenanthroline backbones. In solution at room temperature there is rapid interchange (on the NMR timescale) between the oxygen atoms of the Klaui ligands, which is frozen out on cooling. (C) 2009 Elsevier B. V. All rights reserved.