7-methoxypaclitaxel | 174674-06-7

• 英文名称: 7-methoxypaclitaxel
• 英文别名: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1-hydroxy-9-methoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
• CAS: 174674-06-7
• 化学式: C₄₈H₅₃NO₁₄
• 分子量: 867.947
• InChiKey: DQGXNSWNBDMYGE-JBTWBBNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  63
• 可旋转键数：
  15
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  210
• 氢给体数：
  3
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  2'-triethylsilylpaclitaxel 在 镍 盐酸 、 氢气 、 过氧化苯甲酰 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 20.0 ℃ 、344.75 kPa 条件下， 反应 8.5h， 生成 7-methoxypaclitaxel
  参考文献：
  名称：

  Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers:  Discovery of BMS-184476

  摘要：

  The preparation of C-7 paclitaxel ethers is described. Various substituted ethers were prepared via activation of the corresponding methylthiomethyl ether followed by alcohol addition. Variation of the C-7 ether group as well the 3' side chain position led to the discovery of a novel taxane, BMS-184476 (4), with preclinical antitumor activity superior to paclitaxel.

  DOI：

  10.1021/jm0102607

文献信息

• Water-soluble compound
  申请人：Tuszynski A. Jack

  公开号：US20070092549A1

  公开（公告）日：2007-04-26

  A water-soluble magnetic anti-mitotic compound with a water-solubility of at least 100 micrograms per milliliter, a molecular weight of at least 150 grams per mole, a mitotic index factor of at least 10 percent, a positive magnetic susceptibility of at least 1,000×10 −6 cgs, and a magnetic moment of at least 0.5 bohr magnetrons, wherein said compound is comprised of at least 7 carbon atoms and at least one inorganic atom with a positive magnetic susceptibility of at least 200×10 −6 cgs.
• POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS
  申请人：NITTO DENKO CORPORATION

  公开号：US20170119889A1

  公开（公告）日：2017-05-04

  Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.