1-[N'-(9H-fluoren-9-ylidene)]-3-oxo-5-(2-oxopyrrolidine-1-yl)pyrazolidine-1-ium-2-ide | 1401072-48-7

• 英文名称: 1-[N'-(9H-fluoren-9-ylidene)]-3-oxo-5-(2-oxopyrrolidine-1-yl)pyrazolidine-1-ium-2-ide
• CAS: 1401072-48-7
• 化学式: C₂₀H₁₇N₃O₂
• 分子量: 331.374
• InChiKey: AIZCPRLYTDBJJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  9-芴酮 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 1-[N'-(9H-fluoren-9-ylidene)]-3-oxo-5-(2-oxopyrrolidine-1-yl)pyrazolidine-1-ium-2-ide
  参考文献：
  名称：

  A Tunable Route for the Synthesis of Azomethine Imines and β-Aminocarbonyl Compounds from Alkenes

  摘要：

  Cyclic azomethine imines possessing a beta-aminocarbonyl motif are accessed from simple alkene and hydrazone starting materials. A thermal, concerted alkene aminocarbonylation pathway involving an imino-isocyanate intermediate is proposed and supported by DFT calculations. A notable feature of the process is the steric shielding present in the dipoles formed, which allows for facile purification of the products by chromatography or crystallization. In addition, a fluorenone-derived reagent is reported, which provides reactivity with several alkene classes and allows for mild derivatization of the dipoles into beta-aminoamides, beta-aminoesters, and beta-amino acids.

  DOI：

  10.1021/ja305491t