[[Pd(μ-Br)(κ2N,C-C6H4CH2NMe2)]2] | 26374-71-0

• 英文名称: [[Pd(μ-Br)(κ2N,C-C6H4CH2NMe2)]2]
• 英文别名: [Pd(N,N'-dimethylbenzylamine)(μ-Br)]2；[Pd(dmba)(μ-Br)]2
• CAS: 26374-71-0
• 化学式: C₁₈H₂₄Br₂N₂Pd₂
• 分子量: 641.05
• InChiKey: AHQBESQBWPWLDB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [[Pd(μ-Br)(κ2N,C-C6H4CH2NMe2)]2] 、 N,N'-二丁基-1,2-乙二亚胺 以 氘代氯仿 为溶剂， 生成 [PdBr(dMBA)](t-Bu-dim)
  参考文献：
  名称：

  An nmr study of the interaction of α-diimines (rnchchnr) with cyclometallated palladium(ii) compounds [{2-me2nch(z)c6h4pdx}2] (z  h or (s)-me; x  cl, br)

  摘要：

  DOI：

  10.1016/s0022-328x(00)86028-3
• 作为产物：
  描述：

  sodium bromide 、 bis[(benzyldimethylamino)chloropalladium(II)] 以 水 、 丙酮 为溶剂， 生成 [[Pd(μ-Br)(κ2N,C-C6H4CH2NMe2)]2]
  参考文献：
  名称：

  C 2 ,N-dimethylbenzylamine cyclopalladated compounds: evaluation of cytotoxic, mutagenic and antitubercular activities

  摘要：

  Mono- and binuclear cyclometallated Pd(II) compounds containing C,N-chelating dimethylbenzylamine (Hdmba) have been synthesized aiming at investigating their mutagenic properties (Ames test) and cytotoxic activity toward murine tumor cell lines and Mycobacterium tuberculosis. By reactions of [Pd(C (2) ,N-dmba)(mu-X)](2) {X = Br (1), I (2)} with thiourea (tu), in the 1:2 molar ratio, the mononuclear compounds [Pd(C (2) ,N-dmba)(X)(tu)] {X = Br (3), I (4)} were readily obtained. The new compound 4 was characterized by elemental analyses, infrared (IR) and H-1- and C-13{H-1}-NMR spectroscopies. The cytotoxicity assessment of the cyclopalladated compounds 1-4 revealed that the iodo-derivative 4 was the most active toward murine mammary adenocarcinoma (LM3) cells, even more effective than cisplatin. The cyclometallated compounds 1-4 did not demonstrate mutagenic potential according to Ames test results. Compound 4 was only moderately active (MIC = 60 mu g mL(-1)) against M. tuberculosis.Mono- and binuclear cyclopalladated compounds have been synthesized. These complexes displayed cytotoxic levels toward murine mammary adenocarcinoma cells comparable to cisplatin. Cyclopalladated compounds were non-mutagenic in the Ames test, contrary to cisplatin and its analogues.

  DOI：

  10.1007/s00044-015-1339-3

文献信息

• High-Activity Catalysts for Suzuki Coupling and Amination Reactions with Deactivated Aryl Chloride Substrates:  Importance of the Palladium Source
  作者：Robin B. Bedford、Catherine S. J. Cazin、Simon J. Coles、Thomas Gelbrich、Peter N. Horton、Michael B. Hursthouse、Mark E. Light

  DOI：10.1021/om020841+

  日期：2003.3.1

  phosphine adducts to both Suzuki coupling and Buchwald−Hartwig amination reactions with aryl chloride substrates was examined, and the performance of these catalysts versus conventional palladium sources was evaluated. In general the palladacyclic complexes show considerably enhanced activity. Typically, the best activity is seen with tricyclohexylphosphine adducts in Suzuki coupling and tri-tert-butylphosphine

  与通式的烷基膦配体的邻位金属化催化剂的范围内的Pd（X）（κ 2 Ñ，Ç -C 6 ħ 4 CH 2 NME 2）（PR 3）]已被合成，并且五个晶体结构已经确定了实例（R ＝ Cy，X ＝ TFA，OTf，Cl，I； PR 3＝ PCy 2（邻-联苯基），X ＝ TFA）。2种二聚体前体复合物的晶体结构，[的Pd（μ-TFA）（κ 2 Ñ，Ç -C 6 ħ 4 CH 2 NME 2）} 2]和[的Pd（TFA）（κ 2 Ñ，Ç -C 6 ħ 4 CH Ñ我PR）} 2 ]，也被确定。考察了膦加合物在Suzuki偶联反应和Buchwald-Hartwig与芳基氯化物底物的胺化反应中的应用，并评估了这些催化剂相对于常规钯源的性能。通常，四环配合物显示出显着增强的活性。通常，在铃木偶联和三叔丁基三环己基膦加合物中观察到最佳活性。-丁基膦类似物在胺化反应中。在几乎所有进行的胺化反应中，都观察到少量的第二种产物，即4
• Thermal and spectroscopic investigation on N,N-dimethylbenzylamine based cyclopalladated compounds containing isonicotinamide
  作者：Alessandra Stevanato、Antonio E. Mauro、Adelino V. G. Netto

  DOI：10.1007/s10973-009-0251-9

  日期：2009.7

  Synthesis, spectroscopic characterization and thermal analysis of the [Pd(dmba)(Cl)(iso)] (1), [Pd(dmba)(NCO)(iso)] (2), [Pd(dmba)(N3)(iso)] (3) and [Pd(dmba)(Br)(iso)] (4) (dmba = N,N′-dimethylbenzylamine; iso = isonicotinamide) compounds are described in this work. The complexes were investigated by infrared spectroscopy (IR), differential thermal analysis (DTA) and thermogravimetry (TG) and the residues of the thermal decomposition were identified as Pdo by X-ray powder diffraction. The thermal stability order of the complexes varied as [Pd(dmba)(Cl)(iso)] (1) > [Pd(dmba)(Br)(iso)] (4) > [Pd(dmba)(NCO)(iso)] (2) > [Pd(dmba)(N3)(iso)] (3).

  本研究描述了[Pd(dmba)(Cl)(iso)]（1）、[Pd(dmba)(NCO)(iso)]（2）、[Pd(dmba)(N3)(iso)]（3）和[Pd(dmba)(Br)(iso)]（4）（dmba ；= N,N′-二甲基苄胺；iso = 异烟酰胺）化合物。通过红外光谱（IR）、差热分析（DTA）和热重分析（TG）对复合物进行了研究，并通过 X 射线粉末衍射鉴定了热分解残留物为 Pdo。配合物的热稳定性顺序为 [Pd(dmba)(Cl)(iso)] (1) > [Pd(dmba)(Br)(iso)] (4) > [Pd(dmba)(NCO)(iso)] (2) > [Pd(dmba)(N3)(iso)] (3)。