| 1409943-33-4

• CAS: 1409943-33-4
• 化学式: C₂₆H₂₈BF₂N₃O₆S
• 分子量: 559.399
• InChiKey: ZTZXYBXENDYGNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  3,5-dichloro-8-(4-tolyl) BODIPY 在 sodium hydride 作用下， 以 乙腈 、 mineral oil 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  BODIPY-Based Ratiometric Fluorescent Sensor for Highly Selective Detection of Glutathione over Cysteine and Homocysteine

  摘要：

  We report a ratiometric fluorescent sensor based on monochlorinated BODIPY for highly selective detection of glutathione (GSH) over cysteine (Cys)/homocysteine (Hcy). The chlorine of the monochlorinated BODIPY can be rapidly replaced by thiolates of biothiols through thiol halogen nucleophilic substitution. The amino groups of Cys/Hcy but not GSH further replace the thiolate to form amino-substituted BODIPY. The significantly different photophysical properties of sulfur- and amino-substituted BODIPY enable the discrimination of GSH over Cys and Hcy. The sensor was applied for detection of GSH in living cells.

  DOI：

  10.1021/ja309079f