2-Methyl-4-propan-2-ylthiazinane 1,1-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 2-Methyl-4-propan-2-ylthiazinane 1,1-dioxide
• 英文别名: 2-methyl-4-propan-2-ylthiazinane 1,1-dioxide
• 化学式: C₈H₁₇NO₂S
• 分子量: 191.29
• InChiKey: CGIBZZJEJBVMAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS
  申请人：Acucela Inc.

  公开号：US20160229831A1

  公开（公告）日：2016-08-11

  The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

  本发明涉及治疗神经退行性疾病和疾病的组合物和方法，特别是眼科疾病和疾病。本文提供了替代的3-苯基丙胺衍生物化合物和包含该化合物的药物组合物。所述组合物对于治疗和预防眼科疾病和疾病，包括年龄相关性黄斑变性（AMD）和Stargardt病具有用处。
• Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer
  申请人：Capella Therapeutics, Inc.

  公开号：US10683304B2

  公开（公告）日：2020-06-16

  Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

  本文提供的是苯并咪唑衍生物（例如，式（I））及其药物组合物。本文还提供了使用它们治疗、预防或改善增殖性疾病的一种或多种症状的方法。
• US20140275043A1
  申请人：——

  公开号：US20140275043A1

  公开（公告）日：2014-09-18
• BENZIMIDAZOLE DERIVATIVES AS ERBB TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Capella Therapeutics, Inc.

  公开号：US20170174697A1

  公开（公告）日：2017-06-22

  Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
• BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES
  申请人：Capella Therapeutics, Inc.

  公开号：US20200216419A1

  公开（公告）日：2020-07-09

  Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.