N,N-Dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine | 61452-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: N,N-Dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine
• CAS: 61452-20-8
• 化学式: C₆H₁₂N₂S
• 分子量: 144.24
• InChiKey: AZYIPYFNWWXXLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Inhibitors of factor Xa
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20040116399A1

  公开（公告）日：2004-06-17

  Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

  本发明揭示了一种具有对哺乳动物因子Xa活性的新化合物、其盐和相关组合物。这些化合物在体外或体内用于预防或治疗凝血障碍。
• Benzamides and related inhibitors of factor Xa
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US10179124B2

  公开（公告）日：2019-01-15

  Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

  本研究描述了新型苯甲酰胺化合物，包括其药学上可接受的异构体、盐类、水合物、溶剂和原药衍生物，这些化合物具有抗哺乳动物 Xa 因子的活性。还描述了含有此类化合物的组合物。这些化合物和组合物可用于体外或体内预防或治疗凝血障碍。
• BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20180036296A1

  公开（公告）日：2018-02-08

  Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.