过氯酸镱 | 13498-08-3

• 物质功能分类: 无机化工 - 无机盐 - 金属卤化物及卤酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 镧系含氧阴离子化合物
• 中文名称: 过氯酸镱
• 中文别名: 高氯酸镱；过氯酸镱(III)；高氯酸镱(III)
• 英文名称: Ytterbium(3+) perchlorate
• 英文别名: ytterbium(3+);triperchlorate;hydrate
• CAS: 13498-08-3
• 化学式: Cl3H2O13Yb
• 分子量: 489.4
• InChiKey: TYYKUTNLJJSRBB-UHFFFAOYSA-K

物化性质

• 密度：
  1.474 g/mL at 25 °C
• 稳定性/保质期：

  在常温常压下，该物质是稳定的。请避免与还原剂、易氧化材料、水溶液以及碱金属和碱土金属等许多活性化学药品接触，因为它们不相溶。

计算性质

• 辛醇/水分配系数(LogP)：
  -15.09
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  224
• 氢给体数：
  1
• 氢受体数：
  13

安全信息

• 危险等级：
  5.1
• 危险品标志：
  O,C
• 安全说明：
  S17,S26,S36/37/39,S45
• 危险类别码：
  R8
• 危险品运输编号：
  UN 3211 5.1/PG 2
• 包装等级：
  II
• 危险类别：
  5.1

SDS

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Section 1: Product Identification
Chemical Name: Ytterbium (III) perchlorate, 50% aqueous solution (99.9%-Yb) (REO)
CAS Registry Number: 13498-08-3
Formula: Yb(ClO4)3
EINECS Number: none
Chemical Family: metal perchlorate salt
Synonym: Perchloric acid, Ytterbium(III) salt, aqueous solution

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 13498-08-3 50% no data no data
water 7732-18-5 50% no data no data

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Section 3: Hazards Identification
Irritating to eyes, skin and respiratory tract. May be harmful if swallowed. May affect thyroid and kidney
Emergency Overview:
functions
Primary Routes of Exposure: Ingestion
Eye Contact: Causes moderate irritation of the eyes.
Skin Contact: Causes moderate irritation of the skin.
Inhalation: Irritating to the nose, mucous membranes and respiratory tract.
No specific information is available on the physiological effects of ingestion. May cause gastrointestinal
Ingestion:
irritation, nausea, and vomiting.
Acute Health Affects: Irritating to skin, eyes and respiratory tract.
Chronic Health Affects: Perchlorates reversibly inhibit thyroid iodine uptake. Kidney function may be affected.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: Water spray
Keep sample area wet until fire is completely out. Once dry, product becomes a powerful oxidant, and will act
Special Fire Fighting Procedures:
as a source of oxygen to support combustion.
Hazardous Combustion and If involved in a fire this material may emit corrosive hydrogen chloride fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: May decompose explosively if allowed to dry under fire fighting conditions. Do not mix with combustibles.

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SECTION 6: Accidental Release Measures
Spill and Leak Procedures: Adsorb the liquid into vermiculite or other non combustible adsorbent.

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SECTION 7: Handling and Storage
Handling and Storage: Store in a tightly sealed container in a cool place.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves.
Ventilation: Handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respiratory
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: colorless liq.
Molecular Weight: 471.39
Melting Point: no data
Boiling Point: no data
Vapor Pressure: not applicable
Specific Gravity: no data
Odor: none
Solubility in Water: soluble

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SECTION 10: Stability and Reactivity
Stability: Air and moisture stable liquid
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: Any contact with combustible matter, followed by evaporation of water.
None as aqueous solution. If dried, avoid reducing agents, organic matter, active metals, hydrazine, and
Incompatibility:
strong acids
Decomposition Products: Oxygen, Ytterbium oxide, hydrogen chloride,

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SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: No data available
Mutagenic Effects: No data available
Tetratogenic Effects: No data available

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SECTION 12: Ecological Information
Ecological Information: No data available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Perchlorates, Inorganic, Aqueous solution, N.O.S.
Hazard Class (CFR): 5.1
Additional Hazard Class (CFR): NA
Packaging Group (CFR): II
UN ID Number (CFR): UN# 3211
Shipping Name (IATA): Perchlorates, Inorganic, Aqueous solution, N.O.S.
Hazard Class (IATA): 5.1
Additional Hazard Class (IATA): NA
Packaging Group (IATA): II
UN ID Number (IATA): UN# 3211

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SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory.
SARA (Title 313): Title compound not listed.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

过氯酸镱

过氯酸镱，又称高氯酸镱，是一种稀土高氯酸化合物。它对大鼠背根神经元细胞具有较大的毒性作用，并影响膜上钾通道。

药理活性研究

杜正清等人研究了过氯酸镱（Yb(ClO4)3）诱导大鼠背根神经(DRG)元凋亡、引起胞内钙离子浓度变化以及对膜上钾离子通道的影响。实验中，急性分离大鼠DRG细胞，并用不同浓度的Yb( )3处理24和96小时后，采用流式细胞仪和激光共聚焦法检测细胞的凋亡情况及胞内钙离子荧光强度的变化。利用全细胞膜片钳技术记录了Yb( )3对细胞膜上不同钾通道电流的影响。

结果表明：在10、100和1000μmol/L Yb( )3处理24小时后，DRG神经元基本不表现出凋亡；但在96小时后，细胞出现明显的凋亡（P<0.05～0.01），尤其是1000μmol/L Yb( )3组，凋亡率达到了(55.23±3.76)% (P<0.01)。经Yb( )3孵育的DRG神经元胞内的Ca2+荧光强度显著增大；Yb( )3还抑制背根神经节纤维和神经元突起的生长。

此外，Yb( )3对DRG神经元膜上的钾电流有抑制作用。细胞外液中的Yb( )3不同程度地阻断了瞬间外向钾电流IA（瞬时外向钾电流），对延迟整流钾电流IK几乎没影响；而在电极内液中加入同样浓度的Yb( )3，对IA的影响很小，却特异性地阻断了延迟整流钾电流IK。10μmol/L Yb( )3使IA的激活和失活过程显著右移，延长了瞬时外向钾电流达到峰值的时间及快速失活时间常数，从而增加神经元的兴奋性。