氮化钒 | 24646-85-3

• 物质功能分类: 无机化工 - 无机盐 - 氢化物、氮化物、叠氮化物
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属有机体
• 中文名称: 氮化钒
• 英文名称: Vanadium nitride
• 英文别名: azanylidynevanadium
• CAS: 24646-85-3
• 化学式: VN
• 分子量: 64.948
• InChiKey: SKKMWRVAJNPLFY-UHFFFAOYSA-N

物化性质

• 熔点：
  2320°C
• 密度：
  6.13 g/mL at 25 °C(lit.)
• 溶解度：
  不溶于水；溶于王水

计算性质

• 辛醇/水分配系数(LogP)：
  0.01
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

钒主要通过吸入被吸收，尽管少量可以通过皮肤和消化道吸收。它在血浆中迅速分布，主要分布到肾脏、肝脏、肺、心脏、骨骼，在这些地方它倾向于积累。在细胞色素P-450酶的帮助下，它可以在其两个氧化状态之间相互转化，即钒(IV)（V+4）和钒酸盐（V+5）。钒的这两种状态都可以可逆地与血液中的转铁蛋白结合，然后被红细胞摄取。钒主要通过尿液排出。(L837)

Vanadium is absorbed mainly via inhalation, though small amounts can be absorbed through the skin and gastrointestional tract. It is rapidly distributed in the plasma, mainly to the kidney, liver, lungs, heart, bone, where it tends to accumulate. With the help of cytochrome P-450 enzymes, it can interconvert between its two oxidation states, vanadyl (V+4) and vanadate (V+5). Both states of vanadium can reversibly bind to transferrin protein in the blood and then be taken up into erythrocytes. Vanadium is excreted mainly in the urine. (L837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

钒通过降低巨噬细胞膜的完整性来损害肺泡巨噬细胞，从而损害细胞的吞噬能力和生存能力。钒的五价形式，钒酸盐，是细胞膜上Ca2+-ATP酶和Na+,K+-ATP酶的强效抑制剂，这会降低细胞内ATP的浓度。还认为钒能诱导活性氧种类的产生。这可能会损害DNA并导致氧化应激，从而损害生殖系统。钒还能抑制蛋白质酪氨酸磷酸酶，产生类似胰岛素的效果。

Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration. Vanadium is also believed to induce the production of reactive oxygen species. This may damage DNA and also cause oxidative stress, which can damage the reproductive system. Vanadium also inhibits protein tyrosine phosphatases, producing insulin-like effects. (L837, A247, A248, A249, A250, A251)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

吸入高浓度的钒会影响肺部、喉咙和眼睛。摄入钒可能会导致肾脏和肝脏损伤、出生缺陷或死亡。

Breathing high levels of vanadium affects the lungs, throat, and eyes. Ingestion of vanadium may cause kidney and liver damage, birth defects, or death. (L837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L837）；吸入（L837）；皮肤给药（L837）

Oral (L837) ; inhalation (L837) ; dermal (L837)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

吸入钒会导致肺部刺激、咳嗽、喘息、胸痛、流鼻涕和喉咙痛。

Inhalation of vanadium causes lung irritation, coughing, wheezing, chest pain, runny nose, and a sore throat. (L837)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S36
• 危险类别码：
  R20/21/22
• WGK Germany：
  3

SDS

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Section 1: Product Identification
Chemical Name: Vanadium nitride (99.5%-V)
CAS Registry Number: 24646-85-3
Formula: VN
EINECS Number: 246-382-4
Chemical Family: metal nitride
Synonym: none

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title compound 24646-85-3 100% no data no data

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Section 3: Hazards Identification
Emergency Overview: May be irritating to skin and eyes and respiratory tract.
Primary Routes of Exposure: Ingestion, inhalation
Eye Contact: May be a mild to severe irritant to the eyes.
Skin Contact: May cause slight to mild irritation of the skin.
Inhalation: Do not breath dust. Inhalation of powder may lead to irritation of the respiratory tract.
Ingestion: No information on the physiological effects of ingestion.
Acute Health Affects: May be irritating to skin, eyes, mucous membranes and respiratory tract. Do not breath dust.
Chronic Health Affects: No information available on long-term chronic effects.
NTP: No
IARC: No
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty in
Inhalation:
breathing, coughing, wheezing or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: no data
Explosion Limits: no data
Extinguishing Medium: carbon dioxide, dry powder or foam.
If involved in a fire, fire fighters should be equipped with NIOSH approved positive pressure self-contained
Special Fire Fighting Procedures:
breathing apparatus and full protective clothing.
Hazardous Combustion and No hazardous combustion or decomposition products.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Small spills can be mixed with vermiculite, sodium carbonate or other suitable non combustible adsorbent and
Spill and Leak Procedures:
swept up.

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SECTION 7: Handling and Storage
Handling and Storage: Store the material in a tightly sealed container. Keep away from heat.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respiratory
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: black powder
Molecular Weight: 64.95
Melting Point: 2320°
Boiling Point: no data
Vapor Pressure: no data
Specific Gravity: 6.13
Odor: not determined
Solubility in Water: insoluble

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SECTION 10: Stability and Reactivity
Stability: air and moisture stable
Hazardous Polymerization: No hazardous polymerization.
Conditions to Avoid: none
Incompatibility: oxidizing agents
Decomposition Products: none

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SECTION 11: Toxicological Information
RTECS Data: No information available in the RTECS files.
Carcinogenic Effects: no data
Mutagenic Effects: no data
Tetratogenic Effects: no data

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SECTION 12: Ecological Information
Ecological Information: No information available

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Non-hazardous
Hazard Class (CFR): NA
Additional Hazard Class (CFR): NA
Packaging Group (CFR): NA
UN ID Number (CFR): NA
Shipping Name (IATA): Non-hazardous
Hazard Class (IATA): NA
Additional Hazard Class (IATA): NA
Packaging Group (IATA): NA
UN ID Number (IATA): NA

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SECTION 15: Regulatory Information
TSCA: Listed in the TSCA inventory.
SARA (Title 313): See Category Code N770 for reporting.
Second Ingredient: none

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

制备方法

1. 将化学计量的碳和五氧化二钒充分混合，在氯气气氛中于1250℃下进行还原氮化反应，即可制得氮化钒。也可用氮气-氢气混合气与四氯化钒在1400～1600℃反应制得；或用氨气(NH3)与偏钒酸铵(NH4VO3)在1000～1100℃反应制得。
2. 采用还原法。将化学计量的炭和五氧化二钒充分混合，在氮气气氛中于1250℃下进行还原氮化反应，即可制得氮化钒。也可用氮气-氢气混合气与四氯化钒在1400～1600℃反应制得；或用氨气(NH3)与偏钒酸铵(NH4VO3)在1000～1100℃反应制得。

合成制备方法

1. 将化学计量的碳和五氧化二钒充分混合，在氯气气氛中于1250℃下进行还原氮化反应，即可制得氮化钒。也可用氮气-氢气混合气与四氯化钒在1400～1600℃反应制得；或用氨气(NH3)与偏钒酸铵(NH4VO3)在1000～1100℃反应制得。
2. 采用还原法。将化学计量的炭和五氧化二钒充分混合，在氮气气氛中于1250℃下进行还原氮化反应，即可制得氮化钒。也可用氮气-氢气混合气与四氯化钒在1400～1600℃反应制得；或用氨气(NH3)与偏钒酸铵(NH4VO3)在1000～1100℃反应制得。

反应信息

• 作为反应物：
  描述：

  氮化钒 生成 vanadium nitride
  参考文献：
  名称：

  BOUDART, MICHEL;OYAMA, SHIGEO T.;VOLPE, LEO

  摘要：

  DOI：
• 作为产物：
  描述：

  氨 生成 氮化钒
  参考文献：
  名称：

  BOUDART, MICHEL;OYAMA, SHIGEO T.;VOLPE, LEO

  摘要：

  DOI：

文献信息

• ITINOSEHKI, KEITI;IVABUTI, KEHNGO
  作者：ITINOSEHKI, KEITI、IVABUTI, KEHNGO

  DOI：——

  日期：——
• MAIR, GUNTHER;BITTLER, KNUT;STERZEL, HANS-JOSEF
  作者：MAIR, GUNTHER、BITTLER, KNUT、STERZEL, HANS-JOSEF

  DOI：——

  日期：——
• BOUDART, MICHEL;OYAMA, SHIGEO T.;VOLPE, LEO
  作者：BOUDART, MICHEL、OYAMA, SHIGEO T.、VOLPE, LEO

  DOI：——

  日期：——