(8R)-3-[(2R,4S,5R)-5-(diethoxyphosphorylmethoxymethyl)-4-hydroxyoxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑二氮卓类
• 英文名称: (8R)-3-[(2R,4S,5R)-5-(diethoxyphosphorylmethoxymethyl)-4-hydroxyoxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
• 化学式: C₁₆H₂₇N₄O₇P
• 分子量: 418.38
• InChiKey: BRTZMVZNKRSEKZ-REWJHTLYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• ANTI-CANCER PHOSPHONATE ANALOGS
  申请人：Boojamra Constantine G.

  公开号：US20100022467A1

  公开（公告）日：2010-01-28

  The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗癌化合物、含有这些化合物的组合物以及包括给予这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• Nucleoside Phosphonate Analogs
  申请人：Boojamra Constantine G.

  公开号：US20110071101A1

  公开（公告）日：2011-03-24

  The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
• US7452901B2
  申请人：——

  公开号：US7452901B2

  公开（公告）日：2008-11-18