Streptomyces albulus ATCC 12757

• 分子结构分类: 氧化还原酶 - 作用于配对供体，掺入或还原分子氧 - 以还原铁硫蛋白作为一个供体，并将一个氧原子掺入另一个供体中
• 英文名称: Streptomyces albulus ATCC 12757

反应信息

• 作为试剂：
  描述：

  (Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one 在 Streptomyces albulus ATCC 12757 dipotassium hydrogenphosphate 、 葡萄糖 、 二甲基亚砜 作用下， 反应 66.0h， 生成 (+)-(Z)-2-benzylidene-5(αS)-hydroxy-1-azabicyclo[2.2.2]octan-3-one 、 (-)-(Z)-2-benzylidene-5(βR)-hydroxy-1-azabicyclo[2.2.2]octan-3-one 、 (+)-(Z)-2-benzylidene-5(βS)-hydroxy-1-azabicyclo[2.2.2]octan-3-one 、 (-)-(Z)-2-benzylidene-5(αR)-hydroxy-1-azabicyclo[2.2.2]octan-3-one
  参考文献：
  名称：

  Microbial hydroxylation of (Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one

  摘要：

  Microbial hydroxylation of (Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one 1 by various species of fungi and actinomycetes occurred regio- and stereoselectively at the 5 position of the quinuclidinone moiety. Most of the organisms produced alpha-(5S)-(Z)-2-benzylidene-5-hydroxy-1-azabicyclo[2.2.2]octan-3-one 2 as the major product with enantiomeric excesses ranging from 30% to 84%. The (5 beta)-hydroxy epimer 3 and the (5 alpha,7 alpha)-dihydroxy derivative 4 were also produced by whole cell biotransformations of 1. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00471-1