prostaglandin-E synthase | 52227-79-9

• 分子结构分类: 异构酶 - 分子内氧化还原酶 - 其他分子内氧化还原酶
• 英文名称: prostaglandin-E synthase
• 英文别名: prostaglandin-H2 E-isomerase；endoperoxide isomerase；prostaglandin R-prostaglandin E isomerase；prostaglandin endoperoxide E isomerase；PGE isomerase；PGH-PGE isomerase；PGE2 isomerase；prostaglandin endoperoxide E2 isomerase；prostaglandin H-E isomerase；PGE synthase
• CAS: 52227-79-9

反应信息

• 作为试剂：
  描述：

  [5,6,8,9,11,12,14,15-3H(N)]-花生四烯酸 在 4(3H)-喹唑啉酮,6-氨基-3-(3-氯-2-甲基苯基)-2-甲基- 、 prostaglandin-E synthase glucoso-6-phosphate 、 rabbit liver PG-ketoreductase 、 烟酰胺腺嘌呤双核苷酸磷酸盐 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以75%的产率得到[5,6,8,11,12,14,15-(3)H]-prostaglandin F_2α
  参考文献：
  名称：

  Enzymatic synthesis of tritium labelled eicosanoids

  摘要：

  Methods for the synthesis of tritium labelled prostaglandins, thromboxanes, and hydroxy-derivatives of eicosapolyenoic acids using mono-, two-, and three-enzyme systems have been developed. Optimization of the eicosanoid syntheses with respect to the concentrations of enzymes and eicosapolyenoic acid. time, and temperature of incubation are reported. It is demonstrated that a number of compounds can be produced by enzymatic modifications of prostaglandins and thromboxane. Procedures for the preparation of twenty tritium labelled compounds are described.

  DOI：

  10.1002/(sici)1099-1344(1998080)41:8<741::aid-jlcr123>3.0.co;2-w