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N-acetylneuraminate synthase | 37290-66-7

中文名称
——
中文别名
——
英文名称
N-acetylneuraminate synthase
英文别名
(NANA)condensing enzyme;N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating);NeuAc synthase;N-acetylneuraminate pyruvate lyase
CAS
37290-66-7
化学式
mdl
——
分子量
——
InChiKey
——
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

反应信息

  • 作为试剂:
    描述:
    sodium pyruvate 、 N-thioacetyl-D-mannosamine 在 N-acetylneuraminate synthase sodium azide 、 碳酸氢铵 作用下, 以 为溶剂, 反应 24.0h, 以56%的产率得到ammonium 3,5-dideoxy-5-thioacetamido-D-glycero-D-galacto-2-nonulopyranosonate
    参考文献:
    名称:
    Synthesis of 5-N- and 9-N-thioacylated sialic acids
    摘要:
    N-Thioacylation of neuraminic acid methyl alpha-glycoside (5) with O-ethyl thioformate (1), methyl dithioacetate (2), and methyl dithiopropionate (3) afforded N-thioformyl, N-thioacetyl, and N-thiopropionyl neuraminic acid derivatives 6a-c in high yield. Cleavage of the glycosides was accomplished either by acid hydrolysis or by sialidase treatment. Alternatively, 5-N-thioacylneuraminic acids were produced from the corresponding N-thioacyl-D-mannosamines 7a-c and pyruvate employing N-acetylneuraminate pyruvate lyase. The sialidase-resistant methyl alpha-thioglycoside of N-thioacetylneuraminic acid (10) was also prepared. N-Acetyl-9-deoxy-9-thioacetamido neuraminic acid (19) was obtained either directly by reaction of N-acetyl-9-amino-9-deoxyneuraminic acid (17) with methyl dithioacetate (2) or via its methyl alpha-glycoside 18. Compound 17 was produced from the methyl a-glycoside of 9-O-tosylated methyl ester 12 via the azide 13. -For the 5-N-thioacyl sialic acids 6a-c and 8a-c as well as for the 9-deoxy-9-thioacetamido derivatives 18 and 19 some biological properties are reported.
    DOI:
    10.1016/s0040-4020(01)90473-9
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同类化合物

中文名称暂缺 dimethylallyltranstransferase aminodeoxyfutalosine synthase all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] phosphatidylglycerol---prolipoprotein diacylglyceryl transferase tRNA dimethylallyltransferase 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase caldopentamine synthase beta-(isoxazolin-5-on-4-yl)-L-alanine synthase homogentisate solanesyltransferase [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase heme o synthase all-trans-octaprenyl-diphosphate synthase 6,7-dimethyl-8-ribityllumazine synthase 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase corrinoid adenosyltransferase EutT lycopene elongase/hydratase (flavuxanthin-forming) phosphoglycerol geranylfarnesyltransferase N-(2-amino-2-carboxyethyl)-L-glutamate synthase norspermine synthase N4-bis(aminopropyl)spermidine synthase lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming) 3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase homogentisate phytyltransferase 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase dihydropteroate synthase nerylneryl diphosphate synthase 2-carboxy-1,4-naphthoquinone phytyltransferase 6-linalyl-2-O,3-dimethylflaviolin synthase beta-(isoxazolin-5-on-2-yl)-L-alanine synthase alkylcobalamin dealkylase S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent) cystathionine beta-synthase (O-acetyl-L-serine) flavin prenyltransferase geranylfarnesylglycerol-phosphate geranylfarnesyltransferase coumarin 8-geranyltransferase (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase xanthan ketal pyruvate transferase 2-acylphloroglucinol 4-prenyltransferase 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase flaviolin linalyltransferase homogentisate geranylgeranyltransferase N1-aminopropylagmatine synthase brevianamide F prenyltransferase (deoxybrevianamide E-forming) 2-acyl-4-prenylphloroglucinol 6-prenyltransferase 4-O-dimethylallyl-L-tyrosine synthase 7-dimethylallyltryptophan synthase D-histidine 2-aminobutanoyltransferase lycopaoctaene synthase umbelliferone 6-dimethylallyltransferase