4-(2,2-dimethoxy-ethyl)-homomorpholine | 749879-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧氮杂卓类
• 英文名称: 4-(2,2-dimethoxy-ethyl)-homomorpholine
• 英文别名: 4-(2,2-Dimethoxyethyl)-1,4-oxazepane
• CAS: 749879-63-8
• 化学式: C₉H₁₉NO₃
• 分子量: 189.255
• InChiKey: RNPPTSZCJOIOTI-UHFFFAOYSA-N

物化性质

• 沸点：
  232.8±35.0 °C(Predicted)
• 密度：
  0.996±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2,2-dimethoxy-ethyl)-homomorpholine 在 盐酸 、 水 作用下， 生成 homomorpholin-4-yl-acetaldehyde-hydrochloride
  参考文献：
  名称：

  [DE] BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, IHRE VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
  [EN] BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR THE PRODUCTION THEREOF
  [FR] HETEROCYCLES BICYCLIQUES, MEDICAMENTS LES CONTENANT, LEUR UTILISATION ET LEURS PROCEDES DE PRODUCTION

  摘要：

  The present invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, Rd, Re, and X are as defined in claim 1, their tautomers, their stereoisomers, their mixtures, and their salts, especially their physiologically acceptable salts with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumor diseases as well as benign prostatic hyperplasia (BPH), lung and respiratory diseases, and their production.

  公开号：

  WO2004074263A1
• 作为产物：
  描述：

  2-溴-1,1-二甲氧基乙烷 、 盐酸高吗啉 在 potassium carbonate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 5.0h， 生成 4-(2,2-dimethoxy-ethyl)-homomorpholine
  参考文献：
  名称：

  [DE] BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, IHRE VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
  [EN] BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR THE PRODUCTION THEREOF
  [FR] HETEROCYCLES BICYCLIQUES, MEDICAMENTS LES CONTENANT, LEUR UTILISATION ET LEURS PROCEDES DE PRODUCTION

  摘要：

  The present invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, Rd, Re, and X are as defined in claim 1, their tautomers, their stereoisomers, their mixtures, and their salts, especially their physiologically acceptable salts with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumor diseases as well as benign prostatic hyperplasia (BPH), lung and respiratory diseases, and their production.

  公开号：

  WO2004074263A1

文献信息

• [DE] BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, IHRE VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG<br/>[EN] BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR THE PRODUCTION THEREOF<br/>[FR] HETEROCYCLES BICYCLIQUES, MEDICAMENTS LES CONTENANT, LEUR UTILISATION ET LEURS PROCEDES DE PRODUCTION
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2004074263A1

  公开（公告）日：2004-09-02

  Die vorliegende Erfindung betrifft bicyclische Heterocyclen der allgemeinen Formel (I), in der Ra, Rb, Rc, Rd, Re und X wie im Anspruch 1 definiert sind, deren Tautomere, deren Stereoisomere, deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren, welche wertvolle pharmakologische Eigenschaften aufweisen, insbesondere eine Hemmwirkung auf die durch Tyrosinkinasen vermittelte Signaltransduktion, deren Verwendung zur Behandlung von Krankheiten, insbesondere von Tumorerkrankungen sowie der benignen Prostatahyperplasie (BPH), von Erkrankungen der Lunge und der Atemwege und deren Herstellung.

  The present invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, Rd, Re, and X are as defined in claim 1, their tautomers, their stereoisomers, their mixtures, and their salts, especially their physiologically acceptable salts with inorganic or organic acids, which have valuable pharmacological properties, especially an inhibitory effect on signal transduction mediated by tyrosine kinases, their use in the treatment of diseases, especially tumor diseases as well as benign prostatic hyperplasia (BPH), lung and respiratory diseases, and their production.