4-{[(2S)-Pyrrolidin-2-yl]methyl}thiomorpholine | 760993-48-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 4-{[(2S)-Pyrrolidin-2-yl]methyl}thiomorpholine
• 英文别名: 4-[[(2S)-pyrrolidin-2-yl]methyl]thiomorpholine
• CAS: 760993-48-4
• 化学式: C₉H₁₈N₂S
• 分子量: 186.32
• InChiKey: SJDJIBHRMOPSOD-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS D'AMIDE SUBSTITUÉS BÉTULINIQUES UTILISÉS COMME INHIBITEURS DU VIH
  申请人：HETERO RESEARCH FOUNDATION

  公开号：WO2017017630A1

  公开（公告）日：2017-02-02

  The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

  本发明涉及新的取代苦杏仁酸酰胺化合物的化学式(I)；以及其药用盐，其中R1、R2、R3、R4、R5、R6、R7、R8、X、Y、Z1、Z2、Z3和在此定义的化学式(II)。该发明涉及新的取代苦杏仁酸酰胺衍生物、相关化合物和药物组合物，用于治疗病毒性疾病，特别是HIV介导的疾病。
• METHOD FOR THE PRODUCTION OF CHIRAL AMINOCARBONYL COMPOUNDS
  申请人：List Benjamin

  公开号：US20090281346A1

  公开（公告）日：2009-11-12

  Disclosed is a method for producing aminocarbonyl compounds of the general formula (I) wherein R 1 and R 2 can be identical or different and represents hydrogen, alkyl, alkenyl, alkynyl, or aryl, X represents hydrogen, alkyl, alkenyl, alkynyl, aryl, or OR 3 , R 3 representing hydrogen, alkyl, alkenyl, alkynyl, or aryl. According to said method, an aldehyde of the general formula (II) R 1 CO  (II) wherein R 1 has the meaning indicated above, is reacted with an imine of the general formula (III) wherein R 2 and X have the meaning indicated above, in the presence of a catalyst. Aminocarbonyles are obtained by means of catalyzed Mannich reactions with aldehydes. For example, if α-unbranched aldehydes are reacted with previously formed N-Boc imines in the presence of (S)-proline as a catalyst, the desired β-amino aldehydes are obtained at excellent yields, diastereoselectivities and enantioselectivities.

  本发明公开了一种制备氨基甲酰化合物的方法，其一般式为(I)，其中R1和R2可以相同或不同，表示氢，烷基，烯基，炔基或芳基，X表示氢，烷基，烯基，炔基，芳基或OR3，R3表示氢，烷基，烯基，炔基或芳基。根据所述方法，在催化剂的存在下，将一般式为(II)的醛R1CO(II)与一般式为(III)的亚胺反应，其中R2和X具有上述含义。通过催化曼尼希反应与醛类得到氨基甲酰化合物。例如，如果α-非支链醛与先前形成的N-Boc亚胺在(S)-脯氨酸催化剂的存在下反应，则可以获得所需的β-氨基醛，收率、对映选择性和对映选择性均非常优异。
• US7166586B2
  申请人：——

  公开号：US7166586B2

  公开（公告）日：2007-01-23