1-oxyl-2,2,6,6-tetramethyl-4-(β-aminoethyl)piperidine | 57584-23-3

• 英文名称: 1-oxyl-2,2,6,6-tetramethyl-4-(β-aminoethyl)piperidine
• 英文别名: 4-(β-aminoethyl)-2,2,6,6-tetramethylpiperidin-1-oxyl；4-(β-Aminoethyl)-2,2,6,6-tetramethylpiperidine-1-oxyl
• CAS: 57584-23-3
• 化学式: C₁₁H₂₃N₂O
• 分子量: 199.316
• InChiKey: UAQXVYPBFZIHOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1-oxyl-2,2,6,6-tetramethyl-4-(β-aminoethyl)piperidine 在 亚硝酰氯 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 3.83h， 生成 1-(2-chloroethyl)-1-nitroso-3-[2-(2,2,6,6-tetramethyl-1-oxopiperidin-1-ium-4-yl)ethyl]urea;chloride
  参考文献：
  名称：

  Oxidation and nitrosation of 4-(3-alkylureido)-2, 2, 6, 6-tetramethylpiperidine-1-oxyls to 4-(3-alkyl-3-nitrosoureido)-2, 2, 6, 6-tetramethyl-1-oxopiperidinium salts

  摘要：

  4-(3-Alkylureido)-2,2,6,6-tetramethylpiperidine-1-oxyls are rapidly oxidized by N2O4 or NOCl to 4-(3-alkylureido)-2,2,6,6-tetramethyl-1-oxopiperidinium nitrates and chlorides, which are then nitrosated to 4-(3-alkyl-3-nitrosoureido)-2,2,6,6-tetramethyl-1-oxopiperidinium salts. The perchlorates of the latter were prepared by an exchange reaction with HClO4. The nitrosation of alkylureidooxoammonium salts is the first example of chemical modification of oxoammonium derivatives in which the highly reactive >N+=O group is inert toward the reagent.

  DOI：

  10.1007/bf00698441
• 作为产物：
  描述：

  2,2,6,6-tetramethyl-4-<β-(N-trifluoroacetyl)aminoethyl>piperidine 在 ammonium hydroxide 、 sodium tungstate 、 双氧水 、 ethylene diamine tetraacetic acid tetrasodium salt 作用下， 以 甲醇 、 水 为溶剂， 反应 122.0h， 生成 1-oxyl-2,2,6,6-tetramethyl-4-(β-aminoethyl)piperidine
  参考文献：
  名称：

  Biologically active stable radicals

  摘要：

  DOI：

  10.1007/bf00961762

文献信息

• Synthesis of nitroxide derivatives of alkylnitrosourea
  作者：V. D. Sen'

  DOI：10.1007/bf00698442

  日期：1993.3

  Nitroxide derivatives of alkylnitrosoureas were prepared by the reaction of amino nitroxide radicals with activated N-alkyl-N-nitrosocarbamates or by the selective reduction of oxoammonium derivatives of alkylnitrosoureas.
• Nitroxyl derivatives of pyrazolo [3,4-d]pyrimidine
  作者：V. A. Golubev、Yu. �. Rashba、A. N. Rozenberg

  DOI：10.1007/bf00957715

  日期：1982.12
• ——
  作者：V. D. Sen"、A. V. Shugalii、A. V. Kulikov

  DOI：10.1023/a:1019686323902

  日期：——

  The mixed-ligand complexes cis-Pt-11[R(CH2),NH2](NH3)X-2, where R = 2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl, X-2 = ClI or Cl-2, n = 1 or 2, and binuclear complexes trans-3,4-bis[cis-ammine (iodochloro or dichloro)platinum(II)amino]-2,2,6,6-tetramethylpiperidin-1-oxyls were synthesized. The reactivity of the aminonitroxide complexes toward DNA, the destabilizing effect of the adducts on DNA structure, and the distribution of the Pt adducts along the DNA duplex were studied. The platination activity of the complexes is affected by the natures of both the leaving ligands X and the carrying amino ligands. The decrease in the platination activity of the complexes with an increase in the amino ligand sizes is probably caused by steric hindrance. The complexes that effectively platinate isolated DNA and cause a moderate destabilizition of DNA duplex possess high antitumor activities.