1-thiomorpholin-4-yl-ethanethione | 786686-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 1-thiomorpholin-4-yl-ethanethione
• 英文别名: 1-Thiomorpholin-4-ylethanethione
• CAS: 786686-47-3
• 化学式: C₆H₁₁NS₂
• 分子量: 161.292
• InChiKey: UIEJRJWHYSCMDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  60.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-thiomorpholin-4-yl-ethanethione 、 碘甲烷 以 乙醚 为溶剂， 反应 18.0h， 生成 4-(1-methylsulfanyl-ethyl)-thiomorpholine hydroiodide
  参考文献：
  名称：

  [EN] MUSCARINIC AGONISTS
  [FR] AGONISTES MUSCARINIQUES

  摘要：

  本发明涉及以下式（I）的化合物，它们是M-1肌胆碱受体的激动剂。

  公开号：

  WO2004094363A1

文献信息

• Muscarinic agonists
  申请人：Allen Rebecca Jennifer

  公开号：US20060178438A1

  公开（公告）日：2006-08-10

  The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

  本发明涉及式（I）的化合物，该化合物是M-1肌动蛋白受体的激动剂。
• MUSCARINIC AGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1608617A1

  公开（公告）日：2005-12-28
• PROTECTED MONOMERS AND METHODS OF DEPROTECTION FOR RNA SYNTHESIS
  申请人：Sierzchala Agnieszka B.

  公开号：US20120184724A1

  公开（公告）日：2012-07-19

  A nucleoside monomer that is protected by a thionocarbamate protecting group and contains one or more 2 H, 13 C, or 15 N isotopes in the ribose and/or base part is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.
• PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS
  申请人：Dellinger Douglas J.

  公开号：US20120289691A1

  公开（公告）日：2012-11-15

  A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2′-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2′-protected ribonucleotide residue, which has the following structure: wherein B P is a protected or unprotected heterocycle; R 12 is a protecting group selected from a hydrocarbyl, a substituted hydrocarbyl, an aryl, and a substituted aryl; X is O or S; and PG is a thionocarbamate protecting group.
• Protected Monomer and Method of Final Deprotection for RNA Synthesis
  申请人：Agilent Technologies, Inc.

  公开号：US20160002282A1

  公开（公告）日：2016-01-07

  A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2′-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2′-protected ribonucleotide residue, which has the following structure: wherein B P is a protected or unprotected heterocycle; R 12 is a protecting group selected from a hydrocarbyl, a substituted hydrocarbyl, an aryl, and a substituted aryl; X is O or S; and PG is a thionocarbamate protecting group.