1,3,5-C6H3(C6H4-4-OCH2C2HN3(CH2)3C2(Me)B10H10)3 | 1355254-27-1

• 英文名称: 1,3,5-C6H3(C6H4-4-OCH2C2HN3(CH2)3C2(Me)B10H10)3
• CAS: 1355254-27-1
• 化学式: C₅₁H₈₁B₃₀N₉O₃
• 分子量: 1192.59
• InChiKey: FTQNPMOZMIYBFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• sp3杂化的碳原子比例：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1-(3-azidopropyl)-2-methyl-1,2-dicarba-closododecaborane 、 1,3,5-tris<4-(2-propynyloxy)phenyl>benzene 在 CuSO₄*5H₂O 、 potassium ascorbate 作用下， 以 四氢呋喃 为溶剂， 以85%的产率得到1,3,5-C6H3(C6H4-4-OCH2C2HN3(CH2)3C2(Me)B10H10)3
  参考文献：
  名称：

  “Click” Chemistry-Mediated Phenylene-Cored Carborane Dendrimers

  摘要：

  Phenylene-cored small dendrimers containing three to nine peripheral o-carborane clusters were synthesized via Cu(I)-catalyzed Huisgen-type azide alkyne cycloaddition reactions. The resulting dendrimers have been characterized by IR and NMR spectroscopy and MALDI-TOF mass spectral analysis. The biological evaluation of branched dendrimer 16 containing nine carborane cages has been carried out using human liver cancer cells (SK-Hep1). Dendrimer 16 was accumulated in the SK-Hep1 cancer cells in a concentration-dependent manner. The highest boron accumulation up to 2540 ng of boron/5 X 10(5) cells was observed at a 50 mu M concentration of 16 over a period of 20 h. The high accumulation of 16 into the tumor cell lines indicates that such dendritic boron drug delivery platforms could be possible for application in boron neutron capture therapy in cancer treatment.

  DOI：

  10.1021/om201255b