硒脲酸 | 7783-00-8

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 其他混合金属/非金属含氧阴离子化合物
• 中文名称: 硒脲酸
• 中文别名: 亚硒酸
• 英文名称: selenious acid
• 英文别名: selenous acid；Hydron;selenite
• CAS: 7783-00-8
• 化学式: H₂O₃Se
• 分子量: 128.974
• InChiKey: MCAHWIHFGHIESP-UHFFFAOYSA-N

物化性质

• 熔点：
  70 °C (decomp)
• 密度：
  3.004 g/cm3(Temp: 15 °C)
• 物理描述：
  Solid
• 颜色/状态：
  White hygroscopic crystals.
• 沸点：
  684.9
• 溶解度：
  90 parts/100 parts water @ 0 °C; 400 parts @ 90 °C
• 蒸汽压力：
  2 mm Hg at 15 °C; 4.5 mm Hg at 35 °C; 7 mm Hg at 40.3 °C
• 分解：
  70 °C
• 解离常数：
  2.46
• 稳定性/保质期：
  1. 该物质能被强氧化剂如臭氧、过氧化氢和氯等氧化成硒酸，也能被氢碘酸、亚硫酸、羟胺盐类等还原剂还原成硒。它具有剧毒性，吸入有毒害，并且存在蓄积性危害。与易燃品接触可引起灼烧反应。在干燥空气中会发生风化成为SeO2。易溶于水，是一种中强酸，同时也是中强氧化剂，容易被还原为硒。 2. 亚硒酸及其盐类可通过皮肤渗入使人中毒；口服后呈现剧毒性；无机硒化合物可导致皮炎；接触后可能会出现大蒜味、脸色灰白、紧张和消化不良等症状。常见的工业危害包括刺激和灼烧皮肤。

计算性质

• 辛醇/水分配系数(LogP)：
  -1.61
• 重原子数：
  4.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.53
• 氢给体数：
  2.0
• 氢受体数：
  1.0

ADMET

代谢

被吸收的硒，无论是来自无机源如亚硒酸盐还是有机源包括硒代甲硫氨酸，都会被代谢成氢硒化物，随后被整合到必需的硒蛋白中。在活体内，硒化合物通常被代谢成还原状态。例如，亚硒酸盐中的四价硒（Se+4）常经过还原成为Se−2，首先代谢为H2Se，最终被甲基化成各种排泄形式。硒酸氧化亚硫酸的反应式为：H2SeO3 + 2H2SO3 → Se0 + 2H2SO4 + H2O。硒还可能产生活性氧种，从而发挥对癌细胞的选择性细胞毒性。硒二谷胱甘肽（SDG）是主要的硒代谢物，与两个谷胱甘肽（GSH）分子结合。硒二谷胱甘肽增加了细胞内硒的积累，并且比硒酸（H2SeO3）的毒性大得多。肝脏是硒调节的中心器官，并产生排泄硒形式来调节全身的硒含量。

Absorbed selenium, from both inorganic sources such as selenite and organic sources including selenomethionine, is metabolized to hydrogen selenide, and subsequently incorporated into essential selenoproteins. In vivo, selenium compounds are generally metabolized to reduced states. For example, quadrivalent selenium (Se+4) in selenite often undergoes reduction to Se−2, metabolized firstly to H2Se and, finally, being methylated to various excretory forms. Selenious acid to oxidize sulfurous acid: H2SeO3 + 2H2SO3 → Se0 + 2H2SO4 + H2O. Se may also produce reactive oxygen species and, thereby, exert cancer-selective cytotoxicity. Selenodiglutathione (SDG) is a primary Se metabolite conjugated to two glutathione (GSH) moieties. Selenodiglutathione increases intracellular selenium accumulation and is significantly more toxic than selenous acid (H2SeO3).. The liver is the central organ for selenium regulation and produces excretory selenium forms to regulate whole-body selenium.

来源:DrugBank

代谢

硒可能通过吸入和摄入被吸收，而一些硒化合物也可能通过皮肤被吸收。一旦进入体内，硒主要分布到肝脏和肾脏。硒是一种必需的微量元素，是谷胱甘肽过氧化物酶、碘甲状腺原氨酸5'-脱碘酶和硫氧还蛋白还原酶的组成部分。有机硒首先被代谢成无机硒。无机硒逐步还原为中间体氢硒化物，然后被转化为硒磷酸和硒半胱氨酸tRNA并整合到硒蛋白中，或者在被转化为硒化物的甲基化代谢物后排入尿液中。元素硒在排泄前也会被甲基化。硒主要通过尿液和粪便排出，但某些硒化合物也可能通过呼吸排出。(L619)

Selenium may be absorbed through inhalation and ingestion, while some selenium compounds may also be absorbed dermally. Once in the body, selenium is distributed mainly to the liver and kidney. Selenium is an essential micronutrient and is a component of glutathione peroxidase, iodothyronine 5'-deiodinases, and thioredoxin reductase. Organic selenium is first metabolized into inorganic selenium. Inorganic selenium is reduced stepwise to the intermediate hydrogen selenide, which is either incorporated into selenoproteins after being transformed to selenophosphate and selenocysteinyl tRNA or excreted into the urine after being transformed into methylated metabolites of selenide. Elemental selenium is also methylated before excretion. Selenium is primarily eliminated in the urine and feces, but certain selenium compounds may also be exhaled. (L619)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

硒可以轻易地替代生物分子中的硫，并在许多生化反应中替代硫，特别是在硒的浓度高而硫的浓度低时。通过影响线粒体和微囊电子传递，使细胞呼吸中氧化反应所需的巯基酶失活，这可能是急性硒中毒的一个原因。硒代甲硫氨酸（一种常见的有机硒化合物）似乎也可以随机地替代蛋白质合成中的甲硫氨酸。这种替代可能会影响蛋白质的结构和功能性，例如，通过改变二硫键。无机形态的硒似乎通过氧化还原催化与组织巯基反应，导致形成活性氧种，并通过氧化应激造成损害。（L619）

Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage by oxidative stress. (L619)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌性证据

分类：D；无法归类为人类致癌性。分类依据：基于不充分的数据和动物致癌性不足的证据。各种硒化合物在动物和致突变性研究中的证据是相互矛盾的，难以解释；然而，硒硫化物的证据足以归类为B2（可能的 human致癌物） 。人类致癌性数据：不充分。动物致癌性数据：不充分。

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on inadequate data and inadequate evidence of carcinogenicity in animals. The evidence for various selenium compounds in animal and mutagenicity studies is conflicting and difficult to interpret; however, evidnce for selenium sulfide is sufficient for a B2 (probable human carcinogen) classification . HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Inadequate.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

3, 其对人类致癌性无法分类。

3, not classifiable as to its carcinogenicity to humans. (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

长期口服高浓度硒化合物可能会产生一种叫做硒中毒的疾病。硒中毒的主要症状包括脱发、指甲变脆和神经系统异常（例如四肢麻木和其他奇怪的感觉）。动物研究显示，硒还可能影响精子生产和女性生殖周期。

Chronic oral exposure to high concentrations of selenium compounds can produce a disease called selenosis. The major signs of selenosis are hair loss, nail brittleness, and neurological abnormalities (such as numbness and other odd sensations in the extremities). Animal studies have shown that selenium may also affect sperm production and the female reproductive cycle. (L619)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶和通过吞食被吸收进人体。

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

• 吸收

口服亚硒酸后，根据人类研究，大约有40-70%的剂量被吸收。血浆中的硒以硒蛋白P的形式存在，至少占总血浆硒的40%。在鼠标模型中删除硒蛋白P的基因会改变身体组织中硒的分布，这表明硒蛋白P对于硒的运输是必要的。

The absorption of selenite following oral administration approximately 40-70% of an oral dose, based on studies done in humans. Selenoprotein P, the plasma form of selenium, contains at least 40% of the total selenium in plasma. Deletion of the gene for selenoprotein P in mouse models alters the distribution of selenium in body tissues suggesting that selenoprotein P is necessary for selenium transport.

来源:DrugBank

吸收、分配和排泄

• 消除途径

硒主要通过尿液排出体外。然而，通过粪便也会发生显著的内源性损失。排泄速率与补充剂中使用的硒的化学形态和给药途径有关。其他次要的消除途径包括肺和皮肤。一项对48名挪威女性进行的研究中，给予她们200微克以亚硒酸盐形式补充的硒，通过72小时尿液采样分析表明，亚硒酸盐的吸收率大约为50%。

Selenium is eliminated mainly in the urine. However, significant endogenous losses through the feces can also occur. The rate of excretion varies with the chemical form of selenium used in supplementation and the route of administration. Other minor routes of elimination are lungs and skin. Analysis of 72-hour urine sampling from a study of 48 Norwegian women given a 200 μg supplement of selenium in the form of selenite indicated approximately 50% absorption of selenite.

来源:DrugBank

吸收、分配和排泄

• 分布容积

在摄入和吸收后，来自亚硒酸钠的硒在人类和动物的肝脏和肾脏中含量最高。在一项研究中，从46名意外死亡的健康个体和75名各种疾病受害者的尸体中取得的组织样本进行分析，以测定硒水平和分布。按每单位重量计算的硒水平（以ng/gm湿重计）在组织中的降低顺序如下：肾脏（469）> 肝脏 > 脾脏 > 胰腺 > 心脏 > 大脑 > 肺 > 骨骼 > 骨骼肌。身体中硒含量最高的比例是在骨骼肌中（27.5%）。骨骼（16%）和血液（10%）中测量的硒含量显著较低。在癌症患者的组织中，硒水平低于对照组。在酒精性肝脏中测得的硒浓度最低。

Following oral intake and absorption, selenium from sodium selenite is found in the highest concentrations in the liver and kidneys of humans and animals. In one study, tissue samples taken at autopsy from 46 healthy individuals killed in accidents and from 75 corpses of victims of various diseases to analyze selenium levels and distribution. The per-weight-unit basis of selenium levels ng/gm in wet in tissues decreased in the following order: kidney (469) > liver > spleen > pancreas > heart > brain > lung > bone > skeletal muscle. The highest proportion of body selenium was found in skeletal muscles (27.5%),. Significantly less selenium was measured in bones (16%) and blood (10%). In the tissues of cancer corpses, the selenium levels were lower than levels in the control group. The lowest selenium concentrations were measured in alcoholic livers.

来源:DrugBank

吸收、分配和排泄

在大鼠吸入研究中，94%的亚硒酸在肺部的沉积在四小时内被吸收。相应地，元素硒的吸收率为57%。这项研究还记录了皮肤吸收。基于这些大鼠研究的一个模型预测，由于吸入城市大气中的亚硒酸，人体器官浓度不会显著增加人体负担。

Inhalation studies on rats show that 94% of selenious acid deposited in the lung was absorbed within four hours. The corresponding value for elemental selenium was 57%. Skin absorption was also noted in this study. A model based on these rat studies predicted that organ concentration in man due to inhalation of selenious acid ... in urban atmospheres will not contribute significantly to human body burdens.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

BEAGLE DOGS WERE GIVEN 20-60 UG SELENIUM/KG BODY WT BY INHALATION OF SELENIOUS ACID. VIRTUALLY ALL OF THE INHALED AEROSOL WAS RAPIDLY ABSORBED INTO THE BLOOD FROM THE LUNG, GI TRACT, AND DIRECTLY THROUGH THE NASAL MEMBRANES. SELENIUM THAT WAS ABSORBED INTO THE SYSTEMIC CIRCULATION WAS TRANSLOCATED TO THE LIVER, KIDNEY, PELT, AND BLOOD. LONG TERM RETENTION WAS PRIMARILY IN LIVER, PELT, AND BLOOD.

BEAGLE DOGS WERE GIVEN 20-60 UG SELENIUM/KG BODY WT BY INHALATION OF SELENIOUS ACID. VIRTUALLY ALL OF THE INHALED AEROSOL WAS RAPIDLY ABSORBED INTO THE BLOOD FROM THE LUNG, GI TRACT, AND DIRECTLY THROUGH THE NASAL MEMBRANES. SELENIUM THAT WAS ABSORBED INTO THE SYSTEMIC CIRCULATION WAS TRANSLOCATED TO THE LIVER, KIDNEY, PELT, AND BLOOD. LONG TERM RETENTION WAS PRIMARILY IN LIVER, PELT, AND BLOOD.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1
• 危险品标志：
  T,N
• 安全说明：
  S20/21,S28,S45,S60,S61
• 危险类别码：
  R50/53,R23/25,R33
• 包装等级：
  III
• WGK Germany：
  3
• 危险品运输编号：
  UN 2811/2630/3283
• 危险标志：
  GHS06,GHS08,GHS09
• 危险性描述：
  H301 + H331,H373,H410
• 危险性防范说明：
  P261,P273,P301 + P310,P311,P501
• 储存条件：
  1. 保持贮藏器密封。 2. 将其存放在紧密的容器中，并储存在阴凉、干燥的地方。

SDS

Name:	Selenious acid Material Safety Data Sheet
Synonym:	Monohydrated selenium dioxide; selenous acid
CAS:	7783-00-8

Section 1 - Chemical Product MSDS Name:Selenious acid Material Safety Data Sheet
Synonym:Monohydrated selenium dioxide; selenous acid

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7783-00-8	Selenious acid	98	231-974-7

Hazard Symbols: T N
Risk Phrases: 23/25 33 50/53

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. Danger of cumulative effects.
Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
May cause severe eye irritation. May result in corneal injury.
Skin:
May cause severe skin irritation. May be absorbed through the skin in harmful amounts. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
Ingestion:
May be fatal if swallowed. May cause liver and kidney damage. May cause burns to the digestive tract.
Inhalation:
May be fatal if inhaled. May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema.
Chronic:
Symptoms demonstrated by humans suffering from chronic selenium intoxication, selenosis, include depression, languor, nervousness, dermatitis, gastrointestinal disturbances, giddiness, garlic odor of the breath and sweat, moderate emotional instability, excess dental caries, and in extreme cases, loss of fingernails and partial alopecia (hair loss).

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Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
POISON material. If swallowed, get medical aid immediately. Only induce vomiting if directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
POISON material. If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only with adequate ventilation or respiratory protection.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Poison room locked.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 7783-00-8: United Kingdom, WEL - TWA: (listed as selenium compounds): 0.1 mg TWA (except hydrogen selenide, as Se) United Kingdom, WEL - STEL: (listed as selenium compounds): 0.3 m STEL (except hydrogen selenide, as Se) United States OSHA: 0.2 mg/m3 TWA (as Se) (listed under Selenium compounds).
Belgium - TWA: (listed as selenium compounds): 0.2 mg/m3 VLE (as Japan: (listed as selenium compounds): 0.1 mg/m3 OEL (except SeH2 SeF6, as Se) Malaysia: (listed as selenium compounds): 0.2 mg/m3 TWA (as Se) Netherlands: (listed as selenium compounds): 0.1 mg/m3 MAC (as Se Spain: (listed as selenium compounds): 0.1 mg/m3 VLA-ED (except hydrogen selenide, as Se) Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 70 deg C (dec)
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 70 deg C
Solubility in water: Readily soluble in water
Specific Gravity/Density: Not available.
Molecular Formula: H2SeO3
Molecular Weight: 128.97

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong reducing agents, finely powdered metals.
Hazardous Decomposition Products:
Selenium/selenium oxides.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7783-00-8: VS7175000 LD50/LC50:
Not available.
Oral rat LDLo: 25 mg/kg.
Carcinogenicity:
Selenious acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION
Other No information available.

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: SELENIUM COMPOUND, N.O.S.
Hazard Class: 6.1
UN Number: 3283
Packing Group: II
IMO
Shipping Name: SELENIUM COMPOUND, N.O.S.
Hazard Class: 6.1
UN Number: 3283
Packing Group: II
RID/ADR
Shipping Name: SELENIUM COMPOUND, N.O.S.
Hazard Class: 6.1
UN Number: 3283
Packing group: II
USA RQ: CAS# 7783-00-8: 10 lb final RQ; 4.54 kg final RQ

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 23/25 Toxic by inhalation and if swallowed.
R 33 Danger of cumulative effects.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 20/21 When using do not eat, drink or smoke.
S 28A After contact with skin, wash immediately with
plenty of water.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 7783-00-8: No information available.
Canada
CAS# 7783-00-8 is listed on Canada's DSL List.
CAS# 7783-00-8 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7783-00-8 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

制备方法

1. 室温下将密度为1.18的硝酸与硒反应，直到氮氧化物不再溢出。然后在50-60 ºC下蒸发至干。所得固体用水溶解并过滤，滤液浓缩至原体积的四分之一后冷却结晶，吸滤所得晶体用少量冰水洗涤。合并洗涤液和滤液回收利用，所得结晶经上述方法重结晶，可得试剂亚硒酸。
2. 在瓷皿中将纯净的SeO₂溶于少量水中，在水浴上浓缩至开始析出结晶（操作过程中应避免灰尘进入，否则会还原为硒）。冷却后用玻璃砂芯漏斗抽滤析出的亚硒酸结晶，并用水重结晶一次后抽干。将产物放在两层滤纸之间用力挤压，然后在装有KOH的真空干燥器中放置数日以干燥之。若使用浓硫酸或五氧化二磷作干燥剂，则存放较久可能进一步脱水变成二氧化硒。

合成制备方法

1. 室温下将密度为1.18的硝酸与硒反应，直至氮氧化物不再溢出。
2. 在50-60 ºC下蒸发至干。所得固体用水溶解并过滤，滤液浓缩至原体积的四分之一后冷却结晶，吸滤所得晶体用少量冰水洗涤。合并洗涤液和滤液回收利用，所得结晶经上述方法重结晶，可得试剂亚硒酸。
3. 在瓷皿中将纯净的SeO₂溶于少量水中，在水浴上浓缩至开始析出结晶（操作过程中应避免灰尘进入，否则会还原为硒）。冷却后用玻璃砂芯漏斗抽滤析出的亚硒酸结晶，并用水重结晶一次后抽干。将产物放在两层滤纸之间用力挤压，然后在装有KOH的真空干燥器中放置数日以干燥之。若使用浓硫酸或五氧化二磷作干燥剂，则存放较久可能进一步脱水变成二氧化硒。

用途简介

1. 用作分析试剂，可作为还原剂或氧化剂，还用于制备显色剂。
2. 亚硒酸及盐和酸酐可用作焦磷酸盐镀铜和氰化物镀银的光亮剂。

用途

1. 用作分析试剂，可作为还原剂或氧化剂。还用于制备显色剂。

反应信息

• 作为反应物：
  描述：

  硒脲酸 在 alkali 作用下， 以 not given 为溶剂， 生成 sodium selenite
  参考文献：
  名称：

  Berzelius, J. J., Annales de Chimie et de Physique, 1818, vol. 9, p. 258 - 258

  摘要：

  DOI：
• 作为产物：
  描述：

  selenium tetrachloride * sulfur trioxide 在 水 作用下， 以 neat (no solvent) 为溶剂， 生成 硒脲酸
  参考文献：
  名称：

  Clausnizer, F., Liebigs Annalen der Chemie, 1879, vol. 196, p. 282 - 282

  摘要：

  DOI：
• 作为试剂：
  描述：

  D-青霉胺 在 盐酸 、 硒脲酸 作用下， 以 水 为溶剂， 生成 D-青霉胺二硫化物 、 selenodipenicillamine 、 PenSSe2SPen 、 PenSSe3SPen 、 PenSS4SPen
  参考文献：
  名称：

  生产聚硒二戊二胺，独特的硒化合物。

  摘要：

  亚硒酸盐（H（2）SeO（3））在酸性条件下与硫醇化合物（RSH）反应形成硒代壬二硫醚（RSSeSR，即单硒二硫醇）。建议该反应的化学计量为4RSH + H（2）SeO（3）-> RSSeSR + RSSR + 3H（2）O。出人意料的是，我们在D-青霉胺（PenSH）与H（2）SeO（3）的反应中发现了新型的多核含硒化合物，即聚硒二苯并二胺（PenSSe（2-4）SPen）。通过（1）H-NMR和LC-MS / MS分析确定了PenSSe（2-4）SPen的硒中心特征，表明该化合物的硒同位素丰度模式与理论计算值相符。 。为了更好地了解PenSSe（2-4）SPen生产的机理，将各种摩尔比的H（2）SeO（3）（PenSH的1/8至4倍）与PenSH反应，从PenSSe（1-2）SPen的二甲基质子信号的积分值与乙酸（内标）的甲基质子信号进行比较，计算出产物的浓度。随着H（2）SeO（3）

  DOI：

  10.1248/cpb.58.957

文献信息

• New cadmium-selenium-oxyhalides: Noncentrosymmetric Cd5(SeO3)4Cl2(H2O) and centrosymmetric Cd2(SeO3)F2, Cd2(SeO3)(OH)Br
  作者：Meng Shang、Lili Liu、P. Shiv Halasyamani

  DOI：10.1016/j.jssc.2019.02.033

  日期：2019.5

  Three new cadmium-selenium-oxyhalides, Cd2(SeO3)F2, Cd5(SeO3)4Cl2(H2O) and Cd2(SeO3)(OH)Br, were successfully synthesized by hydrothermal methods. Among these three compounds, Cd5(SeO3)4Cl2(H2O) is noncentrosymmetric (NCS) and crystalizes in the polar space group P21. Powder second-harmonic generation (SHG) measurements using 1064 nm radiation indicate that Cd5(SeO3)4Cl2(H2O) exhibits SHG intensity

  通过水热法成功地合成了三种新的镉-硒卤氧化物Cd 2（SeO 3）F 2， Cd 5（SeO 3）4 Cl 2（H 2 O）和Cd 2（SeO 3）（OH）Br。在这三种化合物中，Cd 5（SeO 3）4 Cl 2（H 2 O）是非中心对称的（NCS），并在极性空间群P 2 1中结晶。使用1064 nm辐射的粉末二次谐波生成（SHG）测量表明Cd 5（SeO3）4 Cl 2（H 2 O）的SHG强度约为KH 2 PO 4（KDP）的0.6倍。Cd 2（SeO 3）F 2和Cd 2（SeO 3）（OH）Br是中心对称的（CS），分别在空间群Pnma和C 2 / c中结晶。Cd 5（SeO 3）4 Cl 2（H 2O）是由相互连接的镉-氧-氯层和镉-氧-氯链构成的，其中的Se离子通过共享三个氧原子嵌入其中。Cd 2（SeO 3）F 2表现出具有[CdO 3 F 3 ]八面体的三维（3D）结构，该八面体连接到[SeO
• Synthesis of band gap engineered Pb_{<i> <scp>X</scp> </i>} Cd_{<scp>1-</scp> <i> <scp>X</scp> </i>} Se thin films: A study on their optical, electrical, structural and localized mechanical properties
  作者：Nillohit Mukherjee、Gobinda Gopal Khan、Arijit Sinha、Anup Mondal

  DOI：10.1002/pssa.200925286

  日期：2010.8

  electrochemical technique to prepare band gap engineered IV-II-VI type ternary solid solution system of Pb x Cd 1-x Se. This technologically important material is prepared using this method for the first time. We have used a self sufficient modified electrochemical cell made up of Pb anode and a transparent conducting oxide (TCO) coated glass cathode, containing Pb(CH 3 COO) 2 , Cd(CH 3 COO) 2 , H 2 SeO 3 and

  在这项工作中，我们报道了一种新的电化学技术来制备 Pb x Cd 1-x Se 的带隙工程 IV-II-VI 型三元固溶体体系。这种技术上重要的材料是第一次使用这种方法制备的。我们使用了由 Pb 阳极和透明导电氧化物 (TCO) 涂层玻璃阴极组成的自足改性电化学电池，其中包含 Pb(CH 3 COO) 2 、Cd(CH 3 COO) 2 、H 2 SeO 3 和 Na 2适当浓度的 EDTA 溶液作为工作电解质。X 射线衍射 (XRD) 图案分析证实了高度结晶的 Pb x Cd 1-x Se 的形成，而扫描电子显微镜 (SEM) 揭示了具有致密表面形态的均匀沉积。该三元系统的带隙能量 (Eg) 约为 1.4 eV，介于 CdSe (1.77 eV) 和 PbSe (0. 3 eV）并且对太阳能吸收相当好。TCO/Pb x Cd 1-x Se 异质结的良好整流行为由电流-电压测量确定，这表明沉积的三元化合物的
• Syntheses, Crystal Structures, and Properties of New Layered Tungsten(VI)-Containing Materials Based on the Hexagonal-WO3 Structure: M2(WO3)3SeO3 (M = NH4, Rb, Cs)
  作者：William T.A. Harrison、Laurie L. Dussack、Thomas Vogt、Allan J. Jacobson

  DOI：10.1006/jssc.1995.1385

  日期：1995.11

  The hydrothermal syntheses and crystal structures of (NH4)2(WO3)3SeO3 and Cs2(WO3)3SeO3, two new noncentrosymmetric, layered tungsten(VI)-containing phases are reported. Infrared, Raman, and thermogravimetric data are also presented. (NH4)2(WO3)3SeO3 and Cs2(WO3)3SeO3 are isostructural phases built up from hexagonal-tungsten-oxide-like, anionic layers of vertex-sharing WO6 octahedra, capped on one

  报道了（NH 4）2（WO 3）3 SeO 3和Cs 2（WO 3）3 SeO 3的水热合成和晶体结构，这是两个新的非中心对称的层状含钨（VI）相。还介绍了红外，拉曼和热重数据。（NH 4）2（WO 3）3 SeO 3和Cs 2（WO 3）3 SeO 3是由顶点共享WO的六角形钨氧化物类阴离子层构成的同构相6八面体，一侧被硒原子（亚硒酸盐基团）封端。层间NH + 4或Cs +阳离子可提供电荷平衡。根据中子粉末衍射数据，从Rietveld精炼中阐明了（NH 4）2（WO 3）3 SeO 3中的完整H键方案。在这两个阶段中，WO 6八面体在WO 6单元内均显示出3个短的+ 3个长的WO键距分布。（NH 4）2（WO 3）3 SeO 3和Cs 2（WO 3）3 SeO 3与它们的含有钼（VI）的类似物（NH 4）2（MoO 3）3 SeO 3和Cs 2（MoO 3）3 SeO 3是同构的。晶体数据：（NH
• Electrodeposition and Analysis of Tin Selenide Films
  作者：R. D. Engelken、A. K. Berry、T. P. Van Doren、J. L. Boone、A. Shahnazary

  DOI：10.1149/1.2108623

  日期：1986.3.1

  Depot a partir de solutions aqueuses de couches pouvant etre d'amorphes a polycristalllines. Caracterisation electrique et optique

  Depot a partir de solutions aqueuses de couches pouvant etre d'amorphes a polycristalllines。电气化和光学化
• Method of producing pharmacologically pure crystals
  申请人：Stiefel Thomas

  公开号：US08636973B2

  公开（公告）日：2014-01-28

  The present invention relates to means and methods for producing crystals or crystalline substances. In particular, crystals or crystalline substances which are useful as pharmaceutical ingredients can be manufactured.

  本发明涉及生产晶体或结晶物质的方法和手段。特别是，可以制造用作药用成分的晶体或结晶物质。