(Ru(trpy)(bpy)Cl)(ClO4) | 16455-13-3

• 英文名称: (Ru(trpy)(bpy)Cl)(ClO4)
• 英文别名: [Ru(2,2′:6′,2″-terpyridine)(2,2′-bipyridine)Cl]ClO₄；[Ru(2,2′:6′,2″-terpyridine)(2,2′-bipyridine)Cl]ClO4；[Ru(tpy)(bpy)Cl]ClO₄；[Ru(tpy)(bpy)Cl]ClO4；[Ru(Cl)(2,2':6',2''-terpyridine)(2,2'-bipyridine)](ClO4)；[Ru(Cl)(2,2':6',2''-terpyridine)(bipy)](ClO4)
• CAS: 16455-13-3
• 化学式: C₂₅H₁₉ClN₅Ru*ClO₄
• 分子量: 625.433
• InChiKey: CYFVBEYOMRJTBU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (Ru(trpy)(bpy)Cl)(ClO4) 、 水 在 sodium chloride 作用下， 以 二甲基亚砜 为溶剂， 反应 6.0h， 生成 aqua(2,2'-bipyridine)(2,2':6',2''-terpyridine)ruthenium(II)(2+)
  参考文献：
  名称：

  不稳定插入钌（ii）复合物的合成，表征和生物学评估，用于抗癌药物筛选†

  摘要：

  DNA结合和DNA转录抑制被认为是癌症化疗的一种有前途的策略。在此，氯叔吡啶基Ru（II）络合物，[Ru（tpy）（N ^ N）Cl] +（Ru1，N ^ N = 2,2'-联吡啶; Ru2，N ^ N = 3-（吡嗪-2- yl）-作为-triazino [5,6- f ] ac ; Ru3，N ^ N = 3-（吡嗪-2-yl）-作为-triazino [5,6- f ] phenanthrene; Ru4，N ^ N = 3制备了-（吡嗪-2-基）-作为-三嗪[5,6- f ] py ，作为DNA嵌入剂和共价结合抗癌剂。氯配体水解缓慢，辛醇和水的分配系数。Ru2–Ru4在0.6至1.2之间。MALDI-TOF质谱，DNA凝胶电泳证实了Ru2-Ru4的共价和插入DNA结合模式，而Ru1只能共价结合DNA。结果，Ru2-Ru4比Ru1表现出更强的DNA转录抑制活性，更高的细胞摄取效率和更

  DOI：

  10.1039/c6dt01270a
• 作为产物：
  描述：

  (2,2'-bipyridine)(2,2':6',2''-terpyridine)aquoruthenium(II) perchlorate 在 Et₃N 作用下， 以 甲醇 、 丙酮 为溶剂， 生成 (Ru(trpy)(bpy)Cl)(ClO4)
  参考文献：
  名称：

  Ruthenium(II) σ-Acetylide and Carbene Complexes Supported by the Terpyridine−Bipyridine Ligand Set:  Structural, Spectroscopic, and Photochemical Studies

  摘要：

  A series of acetylide- and carbene-ruthenium complexes containing polypyridine ligands, [(tpy)(bpy)RuCdropCR](+) (tpy = 2,2':6',2"-terpyridine, bpy = 2,2'-bipyridine; R = C6H4F-4 (1), C6H4Cl-4 (2), C6H5 (3), C6H4Me-4 (4), C6H4OMe-4 (5), t-Bu (6), (C(6)H(4)CdropC)(n)C6H5 [n = 1 (7) and 2 (8)]) and [(tpy)(bpy)Ru=C(OMe)(CH2R)](2+) (R = C6H4OMe-4 (9), t-Bu (10)) have been prepared. The molecular structures of 4(PF6), 5(PF6), and 9(ClO4)(2) reveal Ru-C distances of 2.025(9), 2.025(7), and 1.933(6) Angstrom, respectively. The Ru(III/II) oxidation waves are irreversible for 1-8 (E-pa = 0.15-0.26 V vs FeCp2+/0) but reversible for 9 and 10 (E-1/2 = 0.99 and 1.00 V, respectively). The absorption bands in the visible region for 1-8 (lambda(max) = 502-526 nm) and 9 and 10 (lambda(max) ca. 410 nm) are assigned as d(pi)(Ru-II) --> pi*(polypyridine) MLCT transitions. Complexes 1-8 weakly emit at lambda(max) = 748-786 nm in CH3CN solution at 298 K (lambda(ex) = 550 nm). Complexes 9 and 10 are nonemissive in CH2Cl2 solution at 298 K, but in glassy n-butyronitrile at 77 K, excitation at lambda = 415 nm produces emission at lambda(max) = 597 and 615 nm, respectively. These emissions are tentatively ascribed as d(pi)(Ru-II) --> pi*(polypyridyl) 3 MLCT in nature. The carbene derivatives 9 and 10 undergo photochemical reactions upon irradiation in solution, and [(tpy)(bpy)RuNdropCCH(3)](2+) and 4-methoxybenzaldehyde were isolated from the photolysis of 9 in CH3CN.

  DOI：

  10.1021/om034379k

文献信息

• Labile ruthenium(<scp>ii</scp>) complexes with extended phenyl-substituted terpyridyl ligands: synthesis, aquation and anticancer evaluation
  作者：Huaiyi Huang、Pingyu Zhang、Yu Chen、Liangnian Ji、Hui Chao

  DOI：10.1039/c5dt02446c

  日期：——

  The present study demonstrated that the anticancer activities of labile Ru(ii) complexes can be efficiently tuned by chelating with different phenyl-substituted terpyridyl ligands.

  本研究表明，通过与不同苯基取代的三吡啶配体螯合，可以有效调控易失性Ru(II)配合物的抗癌活性。
• Calvert, Jeffrey M.; Schmehl, Russell H.; Patrick Sullivan, Inorganic Chemistry, 1983, vol. 22, # 15, p. 2151 - 2162
  作者：Calvert, Jeffrey M.、Schmehl, Russell H.、Patrick Sullivan、Facci, John S.、Meyer, Thomas J.、Murray, Royce W.

  DOI：——

  日期：——