硫化银 | 12249-63-7

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属有机体
• 中文名称: 硫化银
• 英文名称: Sulfanylidenesilver
• CAS: 12249-63-7
• 化学式: AgS
• 分子量: 139.94
• InChiKey: PGWMQVQLSMAHHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.65
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

ADMET

代谢

银及其化合物可以通过吸入被吸收，而银化合物也可以通过口服和皮肤接触被吸收。银在血液中分布到全身，尤其是肝脏。不溶的银盐转化为可溶的银硫化蛋白盐，与RNA、DNA和蛋白质中的氨基酸或羧基团结合，或者被抗坏血酸或儿茶酚胺还原成金属银。金属银被氧化，可能会沉积在组织中，导致银质沉着病。银主要通过粪便排出体外。

Silver and its compounds can be absorbed via inhalation, while silver compounds can also be absorbed orally and dermally. It distributes throughout the body in the blood, particularily to the liver. Insoluble silver salts are transformed into soluble silver sulfide albuminates, bind to amino or carboxyl groups in RNA, DNA, and proteins, or are reduced to metallic silver by ascorbic acid or catecholamines. Metallic silver is oxidized and may deposit in the tissues, causing arygria. Silver is eliminated primarily in the faeces. (L808)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

金属银被氧化并可能在组织中沉积，导致银质沉着病。银离子已知能抑制谷胱甘肽过氧化物酶和Na+,K+-ATP酶活性，分别干扰硒催化的硫醇氧化还原反应和细胞内离子浓度。银纳米粒子被认为会破坏线粒体呼吸链，导致氧化应激、ATP合成减少和DNA损伤。

Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. (L808, A243, A244, A245, A246)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

银本身对人类并不有毒，但大多数银盐都有毒。在大剂量下，银及其化合物可以被吸收进入循环系统，并在各种身体组织中沉积，导致银质病，这种病症会导致皮肤、眼睛和粘膜呈现蓝灰色的色素沉着。银质病是罕见的，尽管据目前所知，这种状况并不会对人的健康造成其他伤害，但它会毁容并且通常是永久性的。银质病的轻微形式有时会被误认为是发绀。

Silver itself is not toxic to humans, but most silver salts are. In large doses, silver and compounds containing it can be absorbed into the circulatory system and become deposited in various body tissues, leading to argyria, which results in a blue-grayish pigmentation of the skin, eyes, and mucous membranes. Argyria is rare, and although, so far as known, this condition does not otherwise harm a person's health, it is disfiguring and usually permanent. Mild forms of argyria are sometimes mistaken for cyanosis. (L809)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L808）；吸入（L808）；皮肤给药（L808）

Oral (L808) ; inhalation (L808) ; dermal (L808)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

长期接触高浓度的银可能会导致一种称为银质病的状况，这是一种皮肤和其他身体组织的蓝灰色色素沉着。银质病是一种永久性的影响，但似乎对健康无害。空气中高浓度银的暴露已经导致呼吸问题、肺和喉咙刺激以及胃痛。银与皮肤的接触可能会导致一些人出现轻微的过敏反应，如皮疹、肿胀和炎症。(L808)

Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. Exposure to high levels of silver in the air has resulted in breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. (L808)

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为试剂：
  描述：

  Sodium 4-pyridinylmethanesulfonate 、 环硫乙烷 在 silver nitrate 硫化氢 、 硫化银 、 氢气 、 水 、 甲醇 作用下， 以 水 为溶剂， 反应 1.73h， 以to afford the title compound as an off-white solid (303 mg)的产率得到1-(2-Mercaptoethyl)-4-sulfomethylpyridinium hydroxide
  参考文献：
  名称：

  2-quaternary heteroarylalkylthio carbapenems having an acid moiety

  摘要：

  公式为：##STR1##的化合物被揭示，其中##STR2##是一种季铵化的，单环或双环的杂环基团，被酸基取代，并且它们的制备和用作抗生素。

  公开号：

  US04952397A1