硫化镉汞 | 1345-09-1

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 过渡金属有机体
• 中文名称: 硫化镉汞
• 中文别名: 镉汞硫化物
• 英文名称: Cadmium mercury sulfide
• 英文别名: cadmium(2+);mercury(2+);disulfide
• CAS: 1345-09-1
• 化学式: CdHgS2
• 分子量: 377.1
• InChiKey: ZYCAIJWJKAGBLN-UHFFFAOYSA-N

物化性质

• 颜色/状态：
  Wurzite lattice. Yellow to deep red as the amount of mercury increases.

计算性质

• 辛醇/水分配系数(LogP)：
  -0.01
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  2
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

毒理性

• 致癌性证据

评估：有足够的人类证据表明镉及其化合物具有致癌性。有足够的实验动物证据表明镉化合物具有致癌性。对于镉金属的致癌性，实验动物中提供的证据有限。在做出整体评估时，工作组考虑到了证据，即离子镉会在包括人类细胞在内的各种真核细胞中引起遗传毒性效应。总体评估：镉及其化合物对人类具有致癌性（第1组）。/镉及其化合物/

Evaluation: There is sufficient evidence in humans for the carcinogenicity of cadmium and cadmium compounds. There is sufficient evidence in experimental animals for the carcinogenicity of cadmium compounds. There is limited evidence in experimental animals for the carcinogenicity of cadmium metal. In making the overall evaluation, the Working Group took into consideration the evidence that ionic cadmium causes genotoxic effects in a variety of types of eukaryotic cells, including human cells. Overall evaluation: Cadmium and cadmium compounds are carcinogenic to humans (Group 1). /Cadmium and cadmium compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：B1；可能的人类致癌物。分类依据：来自职业流行病学研究中的镉证据有限，但在调查者和研究人群之间是一致的。有充分的证据表明，在大鼠和小鼠中通过吸入、肌肉注射和皮下注射具有致癌性。在大鼠和小鼠中的七项研究中，口服镉盐（醋酸盐、硫酸盐、氯化物）没有显示出致癌反应的证据。人类致癌性数据：有限。/根据前美国环保署指南进行的分类/

CLASSIFICATION: B1; probable human carcinogen. BASIS FOR CLASSIFICATION: Limited evidence from occupational epidemiologic studies of cadmium is consistent across investigators and study populations. There is sufficient evidence of carcinogenicity in rats and mice by inhalation and intramuscular and subcutaneous injection. Seven studies in rats and mice wherein cadmium salts (acetate, sulfate, chloride) were administered orally have shown no evidence of carcinogenic response. HUMAN CARCINOGENICITY DATA: Limited. /Classification based on former EPA guidelines/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A2；可疑的人类致癌物。/镉及其化合物，如Cd/

A2; Suspected human carcinogen. /Cadmium and compounds, as Cd/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

镉及其化合物：已知是人类致癌物。

Cadmium and Cadmium Compounds: known to be human carcinogens.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

立即急救：确保已经进行了充分去污。如果患者停止呼吸，开始人工呼吸，最好使用需求阀复苏器、袋阀面罩装置或口袋面罩，按训练进行操作。根据需要执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。/镉及其相关化合物/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Cadmium and Related Compounds/

来源:Hazardous Substances Data Bank (HSDB)