硫酸钾盐

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 中文名称: 硫酸钾盐
• 英文名称: Dipotassium;sulfate
• 英文别名: dipotassium;sulfate
• 化学式: K2O4S
• 分子量: 174.26
• InChiKey: OTYBMLCTZGSZBG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -7.33
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.6
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 吸入症状

咳嗽。喉咙痛。

Cough. Sore throat.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

Redness.

Redness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 眼睛症状

红斑。疼痛。

Redness. Pain.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 摄入症状

腹痛。腹泻。恶心。呕吐。

Abdominal pain. Diarrhoea. Nausea. Vomiting.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 人类毒性摘录

吞下大剂量会导致严重的胃肠道刺激。

SWALLOWING LARGE DOSES CAUSES SEVERE GI IRRITATION.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

• 消除途径

大部分是尿液，也包括皮肤和粪便。

Mostly urine but also skin and feces.

来源:DrugBank

反应信息

• 作为反应物：
  描述：

  硫酸钾盐 生成 三氧化硫
  参考文献：
  名称：

  OLBROT, HENRYKA;STARCZEWSKI, MARIAN;SOKOLOWSKA, TERESA;PIASECKA, BOGUMILA, ZESZ. NAUK. CHEM.,(1988) N19, C. 193-197

  摘要：

  DOI：
• 作为产物：
  描述：

  silver nitrate 生成 硫酸钾盐
  参考文献：
  名称：

  SILMAN, HAROLD, PROD. FINISH., 42,(1989) N, C. 31

  摘要：

  DOI：
• 作为试剂：
  描述：

  1-chlorodibenzo[b,f]thiepin-10(11H)-one 、 氰化铜(II) 、 N-甲基吡咯烷酮 、 氨 在 硫酸,铜(2+)盐,碱性的 苯 、 水 、 盐酸 、 硫酸钾盐 、 silica gel 、 chloroform methanol 、 starting material 作用下， 以 水 为溶剂， 反应 16.0h， 以gave 0.7 g of 9-cyano-10,11-dihydro-11-oxo-dibenzo[b,f]thiepin as pale yellow prismatic crystals的产率得到9-cyano 10,11-dihydro-11-oxo-dibenzo[b,f]thiepin
  参考文献：
  名称：

  Benzo[b,f]thiepan derivitives

  摘要：

  9-(β-羟乙基)哌嗪基-羰基-2-三氟甲基-10,11-二氢二苯并[b,f]噻吩被制备并披露为具有抗炎作用。

  公开号：

  US04228284A1

文献信息

• Process for preparation of intermediates of carbocyclic nucleoside
  申请人：Bristol-Myers Squibb Company

  公开号：US05153352A1

  公开（公告）日：1992-10-06

  A compound of the formula: ##STR1## wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, --CH.sub.2 OH or --OH; and G and D are independently selected from hydrogen, C.sub.1 to C.sub.10 alkyl, --OH, --CH.sub.2 OH, --CH.sub.2 OR.sub.20 wherein R.sub.20 is C.sub.1 to C.sub.6 alkyl, --CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is C.sub.1 to C.sub.10 alkyl, --CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 is the side chain of any of the naturally occuring amino acids and R.sub.23 is hydrogen or --C(O)CH(R.sub.24)(NH.sub.2) wherein R.sub.24 is the side chain of any of the naturally occuring amino acids, --CH.sub.1 SH, --Ch.sub.2 Cl, --Ch.sub.2 F, --CH.sub.2 Br, --CH.sub.2 I, --C(O)H, --CH.sub.2 CN, --CH.sub.2 N.sub.3, --CH.sub.2 NR.sub.1 R.sub.2, --CO.sub.2 R.sub.1, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 OR.sub.20 wherein R.sub.20 is as defined above, --CH.sub.2 CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is as defined above, --CH.sub.2 CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 and R.sub.23 are as defined above, --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2, --Ch.sub.2 OPO.sub.3 H.sub.2, --OCH.sub.2 PO.sub.3 H.sub.2 and --CH.sub.2 CO.sub.2 R.sub.3 wherein R.sub.1 and R.sub.2 are independently selected from hydrogen and C.sub.1 to C.sub.10 alkyl and R.sub.3 is hydrogen, C.sub.1 to C.sub.10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.

  该化合物的化学式为：##STR1## 其中A是嘌呤-9-基团，嘌呤-9-基团的杂环等价物，嘧啶-1-基团或嘧啶-1-基团的杂环等价物；E是氢，--CH.sub.2 OH或--OH；G和D是独立选择的氢，C.sub.1到C.sub.10烷基，--OH，--CH.sub.2 OH，--CH.sub.2 OR.sub.20，其中R.sub.20是C.sub.1到C.sub.6烷基，--CH.sub.2 OC(O)R.sub.21，其中R.sub.21是C.sub.1到C.sub.10烷基，--CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23)，其中R.sub.22是任何天然氨基酸的侧链，R.sub.23是氢或--C(O)CH(R.sub.24)(NH.sub.2)，其中R.sub.24是任何天然氨基酸的侧链，--CH.sub.1 SH，--Ch.sub.2 Cl，--Ch.sub.2 F，--CH.sub.2 Br，--CH.sub.2 I，--C(O)H，--CH.sub.2 CN，--CH.sub.2 N.sub.3，--CH.sub.2 NR.sub.1 R.sub.2，--CO.sub.2 R.sub.1，--CH.sub.2 CH.sub.2 OH，--CH.sub.2 CH.sub.2 OR.sub.20，其中R.sub.20如上所定义，--CH.sub.2 CH.sub.2 OC(O)R.sub.21，其中R.sub.21如上所定义，--CH.sub.2 CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23)，其中R.sub.22和R.sub.23如上所定义，--CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2，--Ch.sub.2 OPO.sub.3 H.sub.2，--OCH.sub.2 PO.sub.3 H.sub.2和--CH.sub.2 CO.sub.2 R.sub.3，其中R.sub.1和R.sub.2独立选择为氢和C.sub.1到C.sub.10烷基，R.sub.3为氢，C.sub.1到C.sub.10烷基，羧基烷基或氨基烷基；或其药学上可接受的盐。
• Process for 3-hydrogen cephems
  申请人：Eli Lilly and Company

  公开号：US04402803A1

  公开（公告）日：1983-09-06

  Cephem compounds having only a hydrogen at the 3-position are prepared by electrolytic reduction of 3-chloro or 3-sulfonyloxy cephems.

  只在3位点有氢原子的头孢菌素化合物是通过电解还原3-氯代或3-磺酸酯氧基头孢菌素制备的。
• Thrombin inhibitors
  申请人：——

  公开号：US20040073025A1

  公开（公告）日：2004-04-15

  Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)—N(R 25 )CH(R 30 )—wherein the nitrogen atom is attached to R 1 , and R 25 and R 30 are independently selected from the group consisting of hydrogen, C 3-6 cycloalkyl, and C 1-6 alkyl, or 2) wherein the nitrogen atom is attached to R 1 , and m is 0, 1, or 2. 1

  本发明的化合物在抑制凝血酶和相关的血栓闭塞方面具有有用的结构式（I），其中u为CH或N；Q为1）-N（R25）CH（R30）-，其中氮原子连接到R1，且R25和R30分别选自氢，C3-6环烷基和C1-6烷基的群组，或2）其中氮原子连接到R1，且m为0，1或2.1。
• Preparation of monocalcium phosphate and phosphoric acid
  申请人：Pennzoil Company

  公开号：US04160657A1

  公开（公告）日：1979-07-10

  Monocalcium phosphate, phosphoric acid and/or potassium phosphate containing fertilizers are produced in a process involving acidulation of phosphate rock with phophoric acid in the presence of added silicon dioxide and potassium ion whereby fluorides contained in the rock are converted to K.sub.2 SiF.sub.6, wherein monocalcium phosphate dissolved in phosphoric acid is formed during acidulation. In an important feature, the K.sub.2 SiF.sub.6 is separated and hydrolyzed to regenerate the K.sub.2 O from K.sub.2 SiF.sub.6 as recycled KH.sub.2 PO.sub.4 /H.sub.3 PO.sub.4 solution for further reaction with fluoride from fresh phosphate rock feed. A portion of the MCP/H.sub.3 PO.sub.4 solution and/or crystallized monocalcium phosphate can then be reacted with potassium sulfate, potassium bisulfate, or mixtures thereof, to form KH.sub.2 PO.sub.4, or KH.sub.2 PO.sub.4 /H.sub.3 PO.sub.4 solutions, and gypsum. In a closely related embodiment, the remaining MCP/H.sub.3 PO.sub.4 solution is reacted with sulfuric acid to produce phosphoric acid product and/or the recycle phosphoric acid required in the phosphate rock acidulation step.

  含有单磷酸钙、磷酸和/或磷酸钾的肥料是通过酸化磷酸岩石与磷酸在加入二氧化硅和钾离子的情况下进行生产的，其中岩石中含有的氟化物被转化为K.sub.2 SiF.sub.6，酸化过程中形成了溶解在磷酸中的单磷酸钙。在一个重要的特征中，K.sub.2 SiF.sub.6被分离和水解以再生K.sub.2 O，作为再循环的KH.sub.2 PO.sub.4/H.sub.3 PO.sub.4溶液，用于与新鲜磷酸盐矿石进料中的氟化物进一步反应。MCP/H.sub.3 PO.sub.4溶液的一部分和/或结晶的单磷酸钙可以与硫酸钾、硫酸氢钾或其混合物反应，形成KH.sub.2 PO.sub.4或KH.sub.2 PO.sub.4/H.sub.3 PO.sub.4溶液和石膏。在一个密切相关的实施方案中，剩余的MCP/H.sub.3 PO.sub.4溶液与硫酸反应，产生磷酸产品和/或在磷酸岩石酸化步骤中需要的再循环磷酸。
• Production of fluoride-free phosphates
  申请人：Pennzoil Company

  公开号：US04222990A1

  公开（公告）日：1980-09-16

  A method is disclosed for the acidulation of phosphate rock and the production of substantially pure alkali metal phosphates, calcium phosphates, and phosphoric acid which are essentially free of fluorides and recovery of the fluorine values from the starting phosphate rock in useful form. The steps of the method comprise initial acidulation of phosphate rock with a phosphoric acid solution containing sufficient alkali metal values to provide R.sub.2 O in the system, where R is alkali metal, to solubilize the phosphates and form an insoluble precipitate comprising a mixture of impurities, sand (SiO.sub.2) and the fluorides, from which the fluorides can be recovered in usable form. In preferred embodiments, after removal of the precipitate containing the fluorides, a portion of the solution of phosphoric acid and calcium phosphate is reacted with sulfuric acid and RHSO.sub.4 or R.sub.2 SO.sub.4 where R is alkali metal, to form a solution of RH.sub.2 PO.sub.4 and phosphoric acid and at least a portion of the RH.sub.2 PO.sub.4 and phosphoric acid solution is recycled to the initial acidulation to provide the R.sub.2 O and phosphoric acid makeup. The remainder of the solution of calcium phosphate and phosphoric acid may be further processed for recovery of useful products such as monocalcium phosphate and/or dicalcium phosphate, phosphoric acid, alkali metal phosphates, and calcium sulfate.

  本发明揭示了一种磷酸岩酸化和生产基本无氟的高纯度碱金属磷酸盐、钙磷酸盐和磷酸的方法，并从起始磷酸岩中回收氟值以得到有用的形式。该方法的步骤包括使用含有足够碱金属值以在系统中提供R.sub.2 O（其中R是碱金属）的磷酸溶液进行磷酸岩的初始酸化，以溶解磷酸盐并形成一种不溶性沉淀物，其中包括杂质、沙子（SiO.sub.2）和氟化物，从中可以回收氟化物以得到可用的形式。在优选实施例中，除去含氟沉淀物后，将磷酸和钙磷酸的一部分溶液与硫酸和RHSO.sub.4或R.sub.2 SO.sub.4（其中R是碱金属）反应，以形成RH.sub.2 PO.sub.4和磷酸的溶液，并且至少将RH.sub.2 PO.sub.4和磷酸溶液的一部分回收到初始酸化中，以提供R.sub.2 O和磷酸补充。钙磷酸和磷酸的其余溶液可以进一步处理以回收有用的产品，例如单一磷酸钙和/或双磷酸钙、磷酸、碱金属磷酸盐和硫酸钙。

表征谱图