1-bromo-2-[2-isocyano-2-(3-methoxyphenyl)propyl]benzene | 1426409-94-0

• 英文名称: 1-bromo-2-[2-isocyano-2-(3-methoxyphenyl)propyl]benzene
• CAS: 1426409-94-0
• 化学式: C₁₇H₁₆BrNO
• 分子量: 330.224
• InChiKey: PMCZTIPYHSSLDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1-bromo-2-[2-isocyano-2-(3-methoxyphenyl)propyl]benzene 以 乙醚 、 正己烷 为溶剂， 反应 0.08h， 以50%的产率得到3-(3-methoxyphenyl)-3-methyl-3,4-dihydroisoquinoline
  参考文献：
  名称：

  Synthesis of 3,4-Dihydroisoquinolines by Cyclization of 1-Bromo-2-(2-isocyanoalkyl)benzenes with Butyllithium

  摘要：

  A new and convenient method for the preparation of 3,3-disubstituted 3,4-dihydroisoquinolines has been developed. Thus, the reaction of 1-bromo-2-(bromomethyl)benzenes with (1-isocyano-1-lithioalkyl)benzenes, generated by the treatment of (1-isocyanoalkyl)benzenes with butyllithium, in THF at -78 degrees C gave the corresponding 1-(2-aryl-2-isocyanoalkyl)-2-bromobenzenes, which in turn were transformed into the desired products on treatment with butyllithium in THF at -78 degrees C.

  DOI：

  10.3987/com-12-12620
• 作为产物：
  描述：

  N-甲酰基-1-(3-甲氧基苯基)乙胺 在 正丁基锂 、 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.25h， 生成 1-bromo-2-[2-isocyano-2-(3-methoxyphenyl)propyl]benzene
  参考文献：
  名称：

  Synthesis of 3,4-Dihydroisoquinolines by Cyclization of 1-Bromo-2-(2-isocyanoalkyl)benzenes with Butyllithium

  摘要：

  A new and convenient method for the preparation of 3,3-disubstituted 3,4-dihydroisoquinolines has been developed. Thus, the reaction of 1-bromo-2-(bromomethyl)benzenes with (1-isocyano-1-lithioalkyl)benzenes, generated by the treatment of (1-isocyanoalkyl)benzenes with butyllithium, in THF at -78 degrees C gave the corresponding 1-(2-aryl-2-isocyanoalkyl)-2-bromobenzenes, which in turn were transformed into the desired products on treatment with butyllithium in THF at -78 degrees C.

  DOI：

  10.3987/com-12-12620