[(η6-p-cymene)Ru(tropolonato-O,O)(H2O)]NO3 | 900493-33-6

• 英文名称: [(η6-p-cymene)Ru(tropolonato-O,O)(H2O)]NO3
• CAS: 900493-33-6
• 化学式: C₁₇H₂₁O₃Ru*NO₃
• 分子量: 436.427
• InChiKey: VGDTYQCGPHYWBO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [(η6-p-cymene)Ru(tropolonato-O,O)(H2O)]NO3 、 三氟甲磺酸钠 以 水 为溶剂， 生成 [(η6-p-cymene)Ru(tropolonato-O,O)(H2O)]CF3SO3
  参考文献：
  名称：

  Ruthenium(II) arene complexes containing four- and five-membered monoanionic O,O-chelate rings

  摘要：

  Optimization of the design of half-sandwich organometallic Ru-II arene complexes as anticancer agents depends on control of ligand exchange reactions. We have studied the aqueous chemistry of complexes containing O,O-chelate rings. The presence of the four-membered O,O-chelate ring from acetate (AcO) in [eta(6)-p-cymene)Ru(AcO)Cl] was confirmed by X-ray crystallography, but in solution the acetate ligand was labile and the hydroxo-bridged dimer [((eta(6)-p-cymene)Ru)(2)(mu-OH)(3)](+) readily formed. The dimer was relatively unreactive towards 9-ethyl guanine. The tropolonato (trop) complex [(eta(6)-p-cymene)Ru(trop)Cl] was stable in aqueous media and the X-ray crystal structure of the aqua adduct [(eta(6)-p-cymene)Ru(trop)(H2O)]CF3SO3, containing a five-membered O,O-chelate ring from trop, was determined. [(eta(6)-p-cymene)Ru(trop)Cl] reacted with guanosine to form N7 adducts and with adenosine to form both N7 and N1 adducts. Competitive reactions with guanosine and adenosine gave rise to guanosine:adenosine adducts in a ca. 1.3:1 mol ratio. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2005.12.059
• 作为产物：
  描述：

  [(η6-p-Cymene)Ru(κ2-O,O-tropolone)Cl] 、 水 、 silver nitrate 以 水 为溶剂， 生成 [(η6-p-cymene)Ru(tropolonato-O,O)(H2O)]NO3
  参考文献：
  名称：

  Ruthenium(II) arene complexes containing four- and five-membered monoanionic O,O-chelate rings

  摘要：

  Optimization of the design of half-sandwich organometallic Ru-II arene complexes as anticancer agents depends on control of ligand exchange reactions. We have studied the aqueous chemistry of complexes containing O,O-chelate rings. The presence of the four-membered O,O-chelate ring from acetate (AcO) in [eta(6)-p-cymene)Ru(AcO)Cl] was confirmed by X-ray crystallography, but in solution the acetate ligand was labile and the hydroxo-bridged dimer [((eta(6)-p-cymene)Ru)(2)(mu-OH)(3)](+) readily formed. The dimer was relatively unreactive towards 9-ethyl guanine. The tropolonato (trop) complex [(eta(6)-p-cymene)Ru(trop)Cl] was stable in aqueous media and the X-ray crystal structure of the aqua adduct [(eta(6)-p-cymene)Ru(trop)(H2O)]CF3SO3, containing a five-membered O,O-chelate ring from trop, was determined. [(eta(6)-p-cymene)Ru(trop)Cl] reacted with guanosine to form N7 adducts and with adenosine to form both N7 and N1 adducts. Competitive reactions with guanosine and adenosine gave rise to guanosine:adenosine adducts in a ca. 1.3:1 mol ratio. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2005.12.059