[RuCl(2,2':6',2''-terpyridine)(dipyrido[3,2-a:2′3′-c]phenazine)]Cl | 1175149-11-7

• 英文名称: [RuCl(2,2':6',2''-terpyridine)(dipyrido[3,2-a:2′3′-c]phenazine)]Cl
• 英文别名: {Ru(dipyridophenazine)(2,2',2''-terpyridine)Cl}Cl；[Ru(2,2’:6’,2’’-terpyridine)(dipyrido[3,2-a:2’,3’-c]phenazine)Cl]Cl；[Ru(tpy)(dppz)Cl]Cl；[ruthenium(II)Cl(2,2':6',2''-terpyridine)(dipyrido[3,2-a:2',3'-c]phenazine]Cl
• CAS: 1175149-11-7
• 化学式: C₃₃H₂₁ClN₇Ru*Cl
• 分子量: 687.553
• InChiKey: XXTQXOUQCXIALI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  ammonium hexafluorophosphate 、 [RuCl(2,2':6',2''-terpyridine)(dipyrido[3,2-a:2′3′-c]phenazine)]Cl 、 水 在 silver toluene-p-sulfonate 作用下， 以 丙酮 、 水 为溶剂， 反应 1.0h， 以81%的产率得到[Ru(terpy)(dppz)(H₂O)](PF₆)₂
  参考文献：
  名称：

  Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles

  摘要：

  Ruthenium(II) polypyridyl complexes have emerged both as promising probes of DNA structure and as anticancer agents because of their unique photophysical and c-ytotoxic properties. A key consideration in the administration of those therapeutic agents is the optimization of their chemical reactivities to allow facile attack on the target sites, yet avoid unwanted side effects. Here, we present a drug delivery platform technology, obtained by grafting the surface of mesoporous silica nanoparticles (MSNPs) with ruthenium(II) dipyridophenazine (dppz) complexes. This hybrid nanomaterial displays enhanced luminescent properties relative to that of the ruthenium(II) dppz complex in a homogeneous phase. Since the coordination between the ruthenium(II) complex and a monodentate ligand linked covalently to the nanoparticles can be cleaved under irradiation with visible light, the ruthenium complex can be released from the surface of the nanoparticles by selective substitution of this ligand with a water molecule. Indeed, the modified MSNPs undergo rapid cellular uptake, and after activation with light, the release of an aqua ruthenium(II) complex is observed. We have delivered, in combination, the ruthenium(H) complex and paclitaxel, loaded in the mesoporous structure, to breast cancer cells. This hybrid material represents a promising candidate as one of the so-called theranostic agents that possess both diagnostic and therapeutic functions.

  DOI：

  10.1021/ja405058y
• 作为产物：
  描述：

  二吡啶并[3,2-a:2',3'-c]吩嗪 、 Ru(tpy)(Cl)₃ 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.03h， 以99%的产率得到[RuCl(2,2':6',2''-terpyridine)(dipyrido[3,2-a:2′3′-c]phenazine)]Cl
  参考文献：
  名称：

  一系列三联吡啶钌水氧化催化剂中基于 π-延伸的强配体稳定性

  摘要：

  研究了单齿氯化物配体的稳定性与一组基于联吡啶π-延伸的钌(II)三联吡啶配合物的催化水氧化性能之间的相关性。这些发现得到了理论计算的支持，并表明氯配体的稳定性对 π 延伸的显着依赖性，因此催化周转数和周转频率降低。

  DOI：

  10.1002/chem.202102905

文献信息

• Ruthenium(II) Terpyridyl Complexes Exhibiting DNA Photocleavage: The Role of the Substituent on Monodentate Ligand
  作者：Qian-Xiong Zhou、Fan Yang、Wan-Hua Lei、Jing-Rong Chen、Chao Li、Yuan-Jun Hou、Xi-Cheng Ai、Jian-Ping Zhang、Xue-Song Wang、Bao-Wen Zhang

  DOI：10.1021/jp905506w

  日期：2009.8.20

  at 77 K, and enhancement of the DNA photocleavage ability. DNA photocleavage control experiments and the EPR spin-trapping technique confirm that the photocleavage abilities of the complexes originate from 1O2 production. Time-resolved absorption spectra suggest that the 3MLCT lifetime plays an important role in the photosensitized 1O2 generation of these complexes, which in turn depends strongly on

  五个钌（II）配合物[Ru（II）（tpy）（dppz）（py-R）] 2+（tpy = 2,2'：6'，2''-叔吡啶; dppz = dipyrido [3,2 -a：2′，3′- c ]吩嗪；合成了py-R ＝ 4-取代的吡啶； R ＝ N（CH 3）2，NH 2，OCH 3，H，NO 2）。并仔细研究了取代基对配合物的光物理性质，电化学性质，DNA结合和DNA光解的影响。取代基R的供电子能力从NO 2增加到N（CH 3）2会导致Ru基氧化电位的阴极移位，即1的红移室温下的MLCT吸收和77 K下的3 MLCT发射，并增强了DNA的光裂解能力。DNA光裂解控制实验和EPR自旋捕获技术证实了复合物的光裂解能力源自1 O 2的产生。时间分辨的吸收光谱表明3 MLCT寿命在光敏1 O 2中起重要作用 这些配合物的生成，这在很大程度上取决于取代基R的供电子能力。通过将吡啶的取代基从吸电子基团
• Binding of Ru(terpyridine)(pyridine)dipyridophenazine to DNA studied with polarized spectroscopy and calorimetry
  作者：Anna K. F. Mårtensson、Per Lincoln

  DOI：10.1039/c4dt02642j

  日期：——

  Achiral Ru(tpy)(py)dppz²⁺ intercalated into DNA has similar intermolecular interactions as opposite enantiomers of its structural isomer, the “light-switch” complex Ru(bpy)₂dppz²⁺.

  插入到DNA中的无手性Ru（tpy）（py）dppz2+具有与其结构异构体的相反对映体“光开关”配合物Ru（bpy）2dppz2+相似的分子间相互作用。