S-5-(4-chlorophenyl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate | 1101207-03-7

• 英文名称: S-5-(4-chlorophenyl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate
• CAS: 1101207-03-7
• 化学式: C₁₇H₂₂ClNO₃S₂
• 分子量: 387.952
• InChiKey: VQTCSYPORJHMDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.14
• 重原子数：
  24.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  47.89
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  S-5-(4-chlorophenyl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate 在 过氧化双月桂酰 作用下， 以 氯苯 为溶剂， 反应 2.0h， 以56%的产率得到6-chloro-4-((propan-2-ylideneaminooxy)methyl)-3,4-dihydronaphthalen-1(2H)-one
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113
• 作为产物：
  描述：

  acetoxime O-allyl ether 、 O-ethyl S-2-(4-chlorophenyl)-2-oxoethyl carbonodithioate 在 过氧化双月桂酰 作用下， 以 1,2-二氯乙烷 为溶剂， 以64%的产率得到S-5-(4-chlorophenyl)-5-oxo-1-(propan-2-ylideneaminooxy)pentan-2-yl O-ethyl carbonodithioate
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113