(3-methyl-isoxazol-5-ylmethyl)-triphenyl-phosphonium; bromide | 61858-76-2

• 英文名称: (3-methyl-isoxazol-5-ylmethyl)-triphenyl-phosphonium; bromide
• 英文别名: (3-methyl-1,2-oxazol-5-yl)methyl-triphenylphosphanium;bromide
• CAS: 61858-76-2
• 化学式: Br*C₂₃H₂₁NOP
• 分子量: 438.304
• InChiKey: VORJTAPYPJENIZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.48
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  26.03
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (3-methyl-isoxazol-5-ylmethyl)-triphenyl-phosphonium; bromide 在 sodium carbonate 、 间甲酚 作用下， 以 二氯甲烷 为溶剂， 生成 (2S,3S,5R)-3-methyl-3-[(Z)-2-(3-methyl-1,2-oxazol-5-yl)ethenyl]-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and Evaluation of 2β-0xyimino and Alkenylpenicillanic Acid Sulfone Derivatives as β-Lactamase Inhibitors

  摘要：

  The synthesis and in vitro synergies of 2 beta-alkenyl and oxyiminopenam sulfone derivatives are described. Most of the compounds synthesized exhibited good inhibitory activities and synergistic antibacterial activities with piperacillin and ceftriaxone, respectively, against several beta-lactamase producing strains. Particularly the 2 beta-alkenylpenam sulfone derivatives. 1e and 1g, showed good synergistic activity with ceftriaxone against Citrobacter freundi NIH 10018-68 and Proteus vulgaris 20. Also the compounds 2a, 2c, and 2f, 2 beta-oxyiminopenam sulfone derivatives, exhibited improved synergistic activity with piperacillin against Citrobacter freundi NIH 10018-68.

  DOI：

  10.1002/(sici)1521-4184(19991)332:1<7::aid-ardp7>3.0.co;2-m
• 作为产物：
  描述：

  3-甲基异唑-5-甲醇 在 四溴化碳 、 三苯基膦 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 生成 (3-methyl-isoxazol-5-ylmethyl)-triphenyl-phosphonium; bromide
  参考文献：
  名称：

  Synthesis and Evaluation of 2β-0xyimino and Alkenylpenicillanic Acid Sulfone Derivatives as β-Lactamase Inhibitors

  摘要：

  The synthesis and in vitro synergies of 2 beta-alkenyl and oxyiminopenam sulfone derivatives are described. Most of the compounds synthesized exhibited good inhibitory activities and synergistic antibacterial activities with piperacillin and ceftriaxone, respectively, against several beta-lactamase producing strains. Particularly the 2 beta-alkenylpenam sulfone derivatives. 1e and 1g, showed good synergistic activity with ceftriaxone against Citrobacter freundi NIH 10018-68 and Proteus vulgaris 20. Also the compounds 2a, 2c, and 2f, 2 beta-oxyiminopenam sulfone derivatives, exhibited improved synergistic activity with piperacillin against Citrobacter freundi NIH 10018-68.

  DOI：

  10.1002/(sici)1521-4184(19991)332:1<7::aid-ardp7>3.0.co;2-m

文献信息

• Bravo,P. et al., Gazzetta Chimica Italiana, 1976, vol. 106, p. 743 - 759
  作者：Bravo,P. et al.

  DOI：——

  日期：——