4-isobutyl-[1,4]oxazepane | 19344-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧氮杂卓类
• 英文名称: 4-isobutyl-[1,4]oxazepane
• 英文别名: 4-(2-Methylpropyl)-1,4-oxazepane
• CAS: 19344-49-1
• 化学式: C₉H₁₉NO
• 分子量: 157.256
• InChiKey: PASXYSLGONHXTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
  申请人：Deng Yongqi

  公开号：US20120114739A1

  公开（公告）日：2012-05-10

  The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.

  本发明提供了使用吡唑并[1,5-a]嘧啶化合物抑制mTOR的方法以及使用这些化合物进行治疗、预防、抑制或改善与mTOR相关的一种或多种疾病的方法。
• METHOD FOR PRODUCING CARBONYL COMPOUND AND FLOW REACTION SYSTEM USED FOR PRODUCTION OF CARBONYL COMPOUND
  申请人：FUJIFILM Corporation

  公开号：EP4019494A1

  公开（公告）日：2022-06-29

  There are provided a method of producing a carbonyl compound by a flow type reaction, including introducing a triphosgene solution, a tertiary amine solution, and an active hydrogen-containing compound solution into flow channels different from each other to cause the respective solutions to flow inside the respective flow channels, joining the respective solutions that flow inside the respective flow channels simultaneously or sequentially so that a reaction between phosgene and an active hydrogen-containing compound occurs, and obtaining a carbonyl compound in a joining solution, in which a non-aqueous organic solvent is used as a solvent of each of the respective solutions and a compound having a cyclic structure is used as the tertiary amine; and a flow type reaction system that is suitable for carrying out this production method.

  提供了一种通过流动型反应生产羰基化合物的方法，包括将三光气溶液、叔胺溶液和活性含氢化合物溶液引入彼此不同的流动通道，使各自的溶液在各自的流动通道内流动、将在各自流道内流动的各自溶液同时或依次加入，使光气和活性含氢化合物发生反应，并在加入溶液中获得羰基化合物，其中使用非水有机溶剂作为各自溶液的溶剂，并使用具有环状结构的化合物作为叔胺；以及适用于实施该生产方法的流动式反应系统。