5-(2,5-dimethylphenoxy)-2-methylpentanoic acid chloride | 443924-77-4

• 英文名称: 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid chloride
• CAS: 443924-77-4
• 化学式: C₁₄H₁₉ClO₂
• 分子量: 254.757
• InChiKey: IKLIMNVZHUFAOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.86
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  5-(2,5-dimethylphenoxy)-2-methylpentanoic acid chloride 在 正丁基锂 、 过氧化氢,锂盐(1:1) 作用下， 以 四氢呋喃 为溶剂， 反应 1.25h， 生成 (-)-5-(2,5-dimethylphenoxy)-2-methylpentanoic acid
  参考文献：
  名称：

  Synthesis and antiplatelet activity of gemfibrozil chiral analogues

  摘要：

  The chiral analogues of gemfibrozil 5-(2.5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. from these data. one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00021-5
• 作为产物：
  描述：

  sodium 2,5-dimethylphenolate 在 氢氧化钾 、 氯化亚砜 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 、 乙醇 、 二氯甲烷 为溶剂， 生成 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid chloride
  参考文献：
  名称：

  Synthesis and antiplatelet activity of gemfibrozil chiral analogues

  摘要：

  The chiral analogues of gemfibrozil 5-(2.5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. from these data. one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00021-5

文献信息

• Ligand-Promoted Alkylation of C(sp³)–H and C(sp²)–H Bonds
  作者：Ru-Yi Zhu、Jian He、Xiao-Chen Wang、Jin-Quan Yu

  DOI：10.1021/ja508165a

  日期：2014.9.24

  9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp3)–H and C(sp2)–H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.

  9-甲基吖啶被确定为一种普遍有效的配体，可促进 Pd(II) 催化的 C(sp3)-H 和 C(sp2)-H 与各种烷基碘的简单酰胺的烷基化。这种烷基化反应用于制备非天然氨基酸和几何控制的三和四取代丙烯酸。
• Ligand-Enabled Cross-Coupling of C(sp³)–H Bonds with Arylsilanes
  作者：Jian He、Ryosuke Takise、Haiyan Fu、Jin-Quan Yu

  DOI：10.1021/jacs.5b00890

  日期：2015.4.15

  Pd(II)-catalyzed cross-coupling of C(sp(3))-H bonds with organosilicon coupling partners has been achieved for the first time. The use of a newly developed quinoline-based ligand is essential for the cross-coupling reactions to proceed.