diamminechlorodihydroxy(phenanthridine)platinum nitrate | 1416911-29-9

• 英文名称: diamminechlorodihydroxy(phenanthridine)platinum nitrate
• 英文别名: dihydroxyphenanthriplatin nitrate
• CAS: 1416911-29-9
• 化学式: C₁₃H₁₇ClN₃O₂Pt*NO₃
• 分子量: 539.835
• InChiKey: CRELLFWBNFSDRN-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  diamminechlorodihydroxy(phenanthridine)platinum nitrate 在 间氯过氧苯甲酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  [EN] PLATINUM COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
  [FR] COMPOSÉS DE PLATINE, COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DU CANCER

  摘要：

  公开号：

  WO2014043243A3
• 作为产物：
  描述：

  phenanthriplatin 、 双氧水 反应 21.0h， 以700 mg的产率得到diamminechlorodihydroxy(phenanthridine)platinum nitrate
  参考文献：
  名称：

  [EN] PLATINUM COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
  [FR] COMPOSÉS DE PLATINE, COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DU CANCER

  摘要：

  公开号：

  WO2014043243A3

文献信息

• [EN] PLATINUM COMPOUNDS HAVING A HETEROCYCLE LIGAND, NANOPARTICLES, AND USES THEREOF<br/>[FR] COMPOSÉS DE PLATINE AYANT UN LIGAND HÉTÉROCYCLIQUE, NANOPARTICULES, ET LEURS UTILISATIONS
  申请人：BLEND THERAPEUTICS

  公开号：WO2015009841A3

  公开（公告）日：2015-10-29
• Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding Assays
  作者：Adam H. Brockman、Haley R. Oller、Benoît Moreau、Kristina Kriksciukaite、Mark T. Bilodeau

  DOI：10.1021/jm501748h

  日期：2015.2.12

  Medicinal chemists have been encouraged in recent years to embrace high speed protein binding assays. These methods employ dialysis membranes in 96-well format or spin filters. Membrane-based methods do not separate lipoprotein binding from albumin binding and introduce interference despite membrane binding controls. Ultracentrifugation methods, in contrast, do not introduce interference if density gradients can be avoided and they resolve lipoprotein from albumin. A new generation of compact, fast ultracentrifuges facilitates the rapid and fully informative separation of plasma into albumin, albumin/fatty acid complex, lipoprotein, protein-free, and chylomicron fractions with no need of salt or sugar density gradients. We present a simple and fast ultracentrifuge method here for two platinum compounds and a taxane that otherwise bound irreversibly to dialysis membranes and which exhibited distinctive lipoprotein binding behaviors. This new generation of ultracentrifugation methods underscores a need to further discuss protein binding assessments as they relate to medicinal chemistry efforts.