tricarbonylchloro(alaninato)ruthenium(II) | 475473-29-1

• 英文名称: tricarbonylchloro(alaninato)ruthenium(II)
• 英文别名: Ru(CO)3Cl-alaninate；Ru(CO)₃Cl-alaninate
• CAS: 475473-29-1
• 化学式: C₆H₆ClNO₅Ru
• 分子量: 308.64
• InChiKey: ZZCLJMRUPUTXAY-PUAMRSTPSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  dichlorotricarbonylruthenium(II) dimer 、 DL-丙氨酸 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以89.3%的产率得到tricarbonylchloro(alaninato)ruthenium(II)
  参考文献：
  名称：

  Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal

  摘要：

  In this paper, drug-like properties of two series of carbonyl metal CO-releasing molecules, Ru(CO)(3)ClnL (n = 1, L = amino acid or its derivatives 1-7, L=acetylacetone 8 or 2,2 '-bipyridyl 9; n = 2, L=aminopyridine derivatives 10-13; n = 0, L=salicylaldehyde Schiff base 14-15) and M(CO)(5)L(M = Cr, Mo, W; L = glycine methyl ester 16-18; L=N-methyl imidazole 19-21), were preliminarily evaluated from four aspects involving in cytotoxicity, in vivo toxicity, bio-distribution and metabolism. Cytotoxic effects of all complexes were assayed by mu. IC50 values of complexes 1-15 were 39.55-240.16 mg/l, and those of complexes 16 and 18 were 21.36-22.21 mg/l. Toxicity tests of mice used oral acute toxic class method and got LD50 values of some complexes; among them, LD50 of complex 1 was in 800-1000 mg/kg, complex 7 in 1100-1500 mg/kg and complex 18 in 75-125 mg/kg. After several consecutive administrations, tested complexes severely damaged liver and kidney in both functional and morphological aspects. And by metal ions measurements using ICP-AES, we found that the tested complexes were unevenly distributed in tissues and organs. In vivo, Ru-II in complexes was oxidized to Ru-III by P450 enzymes, and for Mo-0 and W-0 in complexes, part of them transformed into higher oxidation state, the others kept original state. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.12.041

文献信息

• Structural Modifications on CORM-3 Lead to Enhanced Anti-angiogenic Properties Against Triple-negative Breast Cancer Cells
  作者：Malamati Kourti、Jun Cai、Wen Jiang、Andrew D. Westwell

  DOI：10.2174/1573406415666191206102452

  日期：2020.12.29

  molecules (CORMs) are a special class of organometallic complexes that have been reported to offer beneficial effects against different conditions including several subtypes of cancer. Especially for the aggressive and poorly treated triplenegative breast cancer (TNBC), early CORMs have been shown to diminish malignant angiogenesis and may be considered as an alternative approach. So, this study aimed at

  目的：一氧化碳释放分子（CORM）是一类特殊的有机金属配合物，据报道可对包括多种癌症亚型在内的不同疾病提供有益的作用。特别是对于侵略性和治疗不良的三阴性乳腺癌（TNBC），早期CORM已被证明可减少恶性血管生成，可被视为替代方法。因此，本研究旨在测试新的CORM分子在TNBC中的抗血管生成作用，寻求新疗法的有效候选药物。 方法：根据以往的研究，以CORM-3为先导化合物，合成了15种新的钌基CORM，随后在体外评估了其潜在的抗血管生成特性。