| 174173-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• CAS: 174173-27-4；136686-50-5
• 化学式: C₈H₁₇ClN₇O₃Pt*NO₃
• 分子量: 551.806
• InChiKey: RXLHMZISOWGYPA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  silver nitrate 、 阿昔洛韦 、 cisplatin 以 N,N-二甲基甲酰胺 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  Synthesis and characterization of platinum complexes with acyclovir and some acetylated derivatives: crystal and molecular structure of trans-[9-(2-acetoxyethoxymethyl)guanine-κN⁷]dichloro(η-ethylene)platinum(II)

  摘要：

  By reaction of Zeise's salt with selected, N(9)-alkylated, guanine derivatives L [9-(2-hydroxyethoxymethyl)guanine, acyclovir, L1; 9-(2-acetoxyethoxymethyl)guanine, monoacetylacyclovir, L2; or 9-(2-acetoxyethoxymethyl)-N(2)-acetylguanine, diacetylacyclovir, L3] the complexes trans-[PtCl2(eta-2-C2H4)L] (L = L1, 1; L2, 2; or L3, 3) have been prepared. Crystals of complex 2 were obtained from 1,2-dichloroethane solution and characterized by X-ray crystallography: monoclinic, space group C2/c, a = 41.290(6), b = 4.896(3), c = 18.285(2) angstrom, beta = 112.02(1)-degrees and Z = 8. The refinement converged to R and R' values of 0.0204 and 0.0240, respectively. The metal co-ordination is square planar, involving the ethylene ligand, the two trans chloride ions, and the N(7) atom of the guanine ligand. The Pt...O(6) distance of 3.672(2) angstrom excludes any bonding interaction between these two atoms. The bond lengths and angles are normal. In methanol solution the NMR spectra of complexes 1-3 are consistent with exchange of L with solvent. In chloroform solution the spectra are consistent with N(7) co-ordination of the purine ligand. For 2 the NH2 signal splits into two resonances on lowering the temperature, consistent with restricted rotation of this group about the C(2)-NH2 bond. The N(1)H signal for complex 3 is relatvely downfield, suggesting a hydrogen-bond interaction with the carbonyl oxygen of the C(2)NHCOMe group. Only one rotational isomer for this latter group appears to be present. The complexes [PtCl2(dmso)L] (dmso = dimethyl sulphoxide; L = L1, 4; L2, 5; or L3, 6), [PtCl2L2] (L = L2, 7; or L3, 8) and [PtCl(NH3)2L1]NO3 9 were also synthesized and characterized.

  DOI：

  10.1039/dt9910001867