BREVETOXIN PbTx-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 短裸甲藻毒素及其衍生物
• 英文名称: BREVETOXIN PbTx-1
• 英文别名: 2-[(41-hydroxy-4,8,10,46-tetramethyl-14-oxo-2,7,13,17,21,28,34,38,43,47-decaoxadecacyclo[25.24.0.03,22.06,20.08,18.012,16.029,48.033,46.035,44.037,42]henpentaconta-24,49-dien-39-yl)methyl]prop-2-enal
• 化学式: C₄₉H₇₀O₁₃
• 分子量: 867.1
• InChiKey: MGVIMUPHKPHTKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  62
• 可旋转键数：
  3
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  13

ADMET

毒理性

• 毒性总结

布雷维毒素是一种神经毒素，它能与神经细胞中的电压门控钠通道结合，导致正常的神经过程受到干扰。

Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes. (L1112)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

对人类无致癌性（未列入国际癌症研究机构IARC清单）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

brevetoxins 是神经毒素，可引起临床上描述为神经毒性贝类中毒的疾病。

Brevetoxins are neurotoxins that cause the illness clinically described as neurotoxic shellfish poisoning. (L1112)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

注射（刺伤/咬伤）(L1815)

Injection (sting/bite) (L1815)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

brevetoxins 是一种神经毒素，临床上描述为神经性贝类中毒的疾病。症状包括呕吐、恶心和多种神经系统症状，如言语不清。

Brevetoxins are neurotoxins that cause the illness clinically described as neurotoxic shellfish poisoning. Symptoms include vomiting and nausea and a variety of neurologic symptoms such as slurred speech. (L1112)

来源:Toxin and Toxin Target Database (T3DB)