2-Methyl-N-formylthiomorpholin | 30188-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 2-Methyl-N-formylthiomorpholin
• 英文别名: 2-Methyl-4-thiomorpholinecarboxaldehyde；2-methylthiomorpholine-4-carbaldehyde
• CAS: 30188-21-7
• 化学式: C₆H₁₁NOS
• 分子量: 145.225
• InChiKey: IEXVIKXLKUOTJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：US20040220169A1

  公开（公告）日：2004-11-04

  The present invention relates to new substituted carboxylic acid amides of general formula 1 wherein A, B and R 1 to R 5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.

  本发明涉及一般式1的新取代羧酸酰胺，其中A、B和R1至R5如权利要求1中所定义，其互变异构体、对映异构体、非对映异构体、它们的混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质。 上述一般式I的化合物以及其互变异构体、对映异构体、非对映异构体、它们的混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，及其立体异构体具有有价值的药理学性质，特别是抗血栓活性和Xa因子抑制活性。
• CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
  申请人：Gillard James

  公开号：US20080132496A1

  公开（公告）日：2008-06-05

  Substituted carboxylic acid amides of general formula wherein A, B, and R 1 to R 5 are as defined herein, and the tautomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, such as antithrombotic activity and factor Xa-inhibiting activity.

  通式为的取代羧酸酰胺，其中A、B和R1至R5的定义如本文所述，以及它们的互变异构体和盐，特别是与无机或有机酸或碱的生理上可接受的盐，具有有价值的性质，如抗血栓活性和Xa因子抑制活性。
• GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
  申请人：CHILDERS Matthew Lloyd

  公开号：US20160272632A1

  公开（公告）日：2016-09-22

  The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

  本发明提供了一种公式（I）的化合物，它们是JAK抑制剂，因此可用于治疗由JAK介导的疾病，如类风湿性关节炎、哮喘、慢性阻塞性肺疾病和癌症。
• NOVEL BISPHOSPHONIC DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION
  申请人：LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)

  公开号：EP0248854A1

  公开（公告）日：1987-12-16
• US4870063A
  申请人：——

  公开号：US4870063A

  公开（公告）日：1989-09-26