(8R)-3-methyl-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑二氮卓类
• 英文名称: (8R)-3-methyl-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
• 化学式: C₇H₁₀N₄O
• 分子量: 166.18
• InChiKey: JNNSCOWHGUCTKG-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  62.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PROCESS FOR PREPARING PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS PHOSPHORAMIDATÉS DE COMPOSÉS NUCLÉOSIDIQUES UTILISABLES EN VUE DU TRAITEMENT D'INFECTIONS VIRALES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014047117A1

  公开（公告）日：2014-03-27

  Processes for the production of nucleoside phosphoramidate compounds having the following Formula I are provided.

  提供生产以下化学式I的核苷酸磷酰胺化合物的工艺。
• NUCLEOTIDES FOR THE TREATMENT OF LIVER CANCER
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US20170029456A1

  公开（公告）日：2017-02-02

  Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents. In certain embodiments, the compounds are nucleoside analogs of Formula I: (I); or a pharmaceutically acceptable salt thereof, wherein Base, Z 1 , Z 2 , Z 3 , Z 4 , V, W, X, Ar, R 1 and R 2 are as described herein.