2-(Hexylamino)oxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 邻苯基羟胺
• 英文名称: 2-(Hexylamino)oxybenzoic acid
• 英文别名: 2-(hexylamino)oxybenzoic acid
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.29
• InChiKey: HSPLSCFQMWZBLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] STAT3 DIMERIZATION INHIBITORS<br/>[FR] INHIBITEURS DE DIMÉRISATION DE STAT3
  申请人：H LEE MOFFITT CANCER CT & RES

  公开号：WO2014070859A1

  公开（公告）日：2014-05-08

  The subject matter disclosed herein relates to compositions and methods of making and using the compositions. In a further aspect, the subject matter disclosed herein relates to inhibitors of STAT3 dimerization. Methods of making these compositions as well as compositions comprising these compositions are also disclosed. Also disclosed are methods of treating or preventing certain cancers by administering to an individual in need thereof and effective amount of the compounds disclosed herein. Still further, disclosed herein are methods of inhibiting STAT3 by contacting a cell with a compound or composition as disclosed herein.

  本文所披露的主题涉及组成物的制备和使用方法。在进一步的方面，本文所披露的主题涉及STAT3二聚化抑制剂。还揭示了制备这些组成物的方法以及包含这些组成物的组合物。还揭示了通过向需要的个体投与所披露的化合物的有效量来治疗或预防某些癌症的方法。此外，本文还揭示了通过将细胞与本文所披露的化合物或组合物接触以抑制STAT3的方法。
• STAT3 DIMERIZATION INHIBITORS
  申请人：H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

  公开号：US20150259366A1

  公开（公告）日：2015-09-17

  The subject matter disclosed herein relates to compositions and methods of making and using the compositions. In a further aspect, the subject matter disclosed herein relates to inhibitors of STAT3 dimerization. Methods of making these compositions as well as compositions comprising these compositions are also disclosed. Also disclosed are methods of treating or preventing certain cancers by administering to an individual in need thereof and effective amount of the compounds disclosed herein. Still further, disclosed herein are methods of inhibiting STAT3 by contacting a cell with a compound or composition as disclosed herein.

  本文所披露的主题涉及到组合物的制备、制造和使用方法。在进一步的方面，本文所披露的主题涉及到STAT3二聚化抑制剂。还披露了制备这些组合物的方法以及包含这些组合物的组合物。同时，本文还披露了通过向需要的个体施用所披露的化合物的有效量来治疗或预防某些癌症的方法。还进一步地，本文披露了通过将细胞与所披露的化合物或组合物接触来抑制STAT3的方法。
• STAT3 dimerization inhibitors
  申请人：H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

  公开号：US10954258B2

  公开（公告）日：2021-03-23

  The subject matter disclosed herein relates to compositions and methods of making and using the compositions. In a further aspect, the subject matter disclosed herein relates to inhibitors of STAT3 dimerization. Methods of making these compositions as well as compositions comprising these compositions are also disclosed. Also disclosed are methods of treating or preventing certain cancers by administering to an individual in need thereof and effective amount of the compounds disclosed herein. Still further, disclosed herein are methods of inhibiting STAT3 by contacting a cell with a compound or composition as disclosed herein.

  本文公开的主题涉及组合物及组合物的制造和使用方法。在另一方面，本文公开的主题涉及 STAT3 二聚化抑制剂。还公开了制造这些组合物的方法以及包含这些组合物的组合物。还公开了通过向有需要的个体施用有效量的本文公开的化合物来治疗或预防某些癌症的方法。此外，本文还公开了通过使细胞与本文公开的化合物或组合物接触来抑制 STAT3 的方法。
• US9822135B2
  申请人：——

  公开号：US9822135B2

  公开（公告）日：2017-11-21