(3S,4R)-6-(1,1-dioxo-1,4-thiazinan-4-yl)-3-hydroxy-4-methyl-6-oxohexanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: (3S,4R)-6-(1,1-dioxo-1,4-thiazinan-4-yl)-3-hydroxy-4-methyl-6-oxohexanamide
• 化学式: C₁₁H₂₀N₂O₅S
• 分子量: 292.35
• InChiKey: KZZXYEDQGOAQKK-BDAKNGLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• CYCLIC DEPSIPEPTIDE COMPOUNDS AND THEIR USES
  申请人：Cypralis Limited

  公开号：US20170007664A1

  公开（公告）日：2017-01-12

  The present invention relates to novel cycloundecadepsipeptide compounds and their analogues which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility. The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analogues for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition of cyclophilin activity.
• US9895412B2
  申请人：——

  公开号：US9895412B2

  公开（公告）日：2018-02-20
• [EN] NOVEL PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF PERIODONTAL DISEASE<br/>[FR] NOUVELLES FORMULATIONS PHARMACEUTIQUES ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE MALADIE PARODONTALE
  申请人：PERIOC LTD

  公开号：WO2014091239A1

  公开（公告）日：2014-06-19

  The present invention relates to novel treatments of periodontal disease by administering a suitable formulation of a cyclophilin inhibitor. The present invention further relates to novel pharmaceutical compositions containing said cyclophilin inhibitor compounds.