4-[fluoro(phenyl)methyl]-3,4,4a,8a-tetrahydro-1H-pyrano[3,2-d]pyrimidine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃嘧啶类
• 英文名称: 4-[fluoro(phenyl)methyl]-3,4,4a,8a-tetrahydro-1H-pyrano[3,2-d]pyrimidine-2,6-dione
• 化学式: C₁₄H₁₃FN₂O₃
• 分子量: 276.26
• InChiKey: NYJFJVSAHWPDQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] HETEROCYCLO COMPOUNDS AS APOPTOTIC INDUCERS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS COMME INDUCTEURS D'APOPTOSE ET LEURS UTILISATIONS
  申请人：KUNMING INST BOTANY CN ACAD

  公开号：WO2014117741A1

  公开（公告）日：2014-08-07

  Disclosed are heterocyclo compounds that have a formula represented by the following: and wherein X, R1, R2, R3, R4, R5, R6, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cancer conditions in mammals including humans, including by way of non-limiting example, prostate, colon, bladder, melanoma, liver, breast, cervical, ovarian, esophagi, glialblastoma, pancreatic and lung cancer.

  本公开揭示了具有以下表示的化学式的杂环化合物：其中X，R1，R2，R3，R4，R5，R6和n如本文所述。这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的多种癌症病况，例如前列腺癌、结肠癌、膀胱癌、黑色素瘤、肝癌、乳腺癌、宫颈癌、卵巢癌、食管癌、神经胶质母细胞瘤、胰腺癌和肺癌等。
• HETEROCYCLO COMPOUNDS AS APOPTOTIC INDUCERS AND USES THEREOF
  申请人：KUNMING INSTITUTE OF BOTANY, CHINESE ACADEMYOF SCIENCES

  公开号：US20150361062A1

  公开（公告）日：2015-12-17

  Disclosed are heterocyclo compounds that have a formula represented by the following: and wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cancer conditions in mammals including humans, including by way of non-limiting example, prostate, colon, bladder, melanoma, liver, breast, cervical, ovarian, esophagi, glialblastoma, pancreatic and lung cancer.
• US9682947B2
  申请人：——

  公开号：US9682947B2

  公开（公告）日：2017-06-20