2-phenyl-4,4a,8,8a-tetrahydro-1H-pyrano[3,4-d][1,3]thiazin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: 2-phenyl-4,4a,8,8a-tetrahydro-1H-pyrano[3,4-d][1,3]thiazin-2-amine
• 化学式: C₁₃H₁₆N₂OS
• 分子量: 248.35
• InChiKey: OTKHEHWPZRJEPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED PHENYL HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS SUBSTITUÉS DE PHÉNYLHEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE
  申请人：PFIZER

  公开号：WO2014125397A1

  公开（公告）日：2014-08-21

  The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula (I), and the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明涉及所披露的化合物、互变异构体和该化合物的药学上可接受的盐，其中所述化合物具有式（I）的结构，变量R1和R2如规范中所定义。还披露了相应的药物组合物、治疗方法、合成方法和中间体。
• Substituted Phenyl Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds
  申请人：PFIZER INC.

  公开号：US20150376207A1

  公开（公告）日：2015-12-31

  The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R 1 and R 2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明涉及公开的化合物、互变异构体和药学上可以接受的该化合物的盐，其中所述化合物具有I式结构，变量R1和R2如说明书中所定义。还公开了相应的药物组合物、治疗方法、合成方法和中间体。
• SUBSTITUTED PHENYL HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS
  申请人：Pfizer Inc.

  公开号：EP2956459A1

  公开（公告）日：2015-12-23
• US9233981B1
  申请人：——

  公开号：US9233981B1

  公开（公告）日：2016-01-12