6-[(E)-1-phenylbut-2-en-2-yl]-7-oxa-1-azabicyclo[4.1.0]heptan-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧氮杂卓类
• 英文名称: 6-[(E)-1-phenylbut-2-en-2-yl]-7-oxa-1-azabicyclo[4.1.0]heptan-4-ol
• 化学式: C₁₅H₁₉NO₂
• 分子量: 245.32
• InChiKey: IPQNWQFGNBVBSM-XNJYKOPJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• OXAZIRIDINE COMPOUND AND PRODUCTION METHOD THEREOF
  申请人：SEED RESEARCH INSTITUTE CO., LTD.

  公开号：US20170327513A1

  公开（公告）日：2017-11-16

  Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, —C(H) (R 6 )— or —C(H) (R 7 )—C(H)(R 8 )—; and R 1 -R 8 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, or a salt thereof.

  提供了一种显示抗真菌活性和细胞毒性的氧杂环丙烷化合物，可望作为一种新的抗真菌剂或抗癌剂，并提供了其生产方法。化合物的结构式如下：其中X为一个单键，—C(H) (R6)—或—C(H) (R7)—C(H)(R8)—；而R1-R8分别为氢原子，可选择性取代的碳氢基团或可选择性取代的杂环基团，或其盐。
• METHOD FOR PRODUCING KAKEROMYCIN AND DERIVATIVES THEREOF
  申请人：OP BIO FACTORY CO., LTD.

  公开号：US20180037555A1

  公开（公告）日：2018-02-08

  Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.

  提供了一种生产kakeromycin及其衍生物的方法，该衍生物表现出抗真菌活性和细胞毒性，并被期望作为新的抗真菌剂或抗癌剂，通过化学合成。一种化合物的生产方法，该化合物由公式（1）表示：其中R是可选取代的烃基或可选取代的杂环基；n为0或1，或其盐，包括将由公式（2）表示的化合物进行氧化反应的步骤：其中R和n如上定义，或其盐。
• NOVEL MICROBIAL PRODUCT HAVING ANTIFUNGAL ACTIVITY
  申请人：Seed Research Institut Co., Ltd.

  公开号：EP3040338A1

  公开（公告）日：2016-07-06

  Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an antifungal agent containing same, and the like.

  本发明提供了一种具有新型母核的化合物，它可以成为一种有前途的药物发现种子化合物，并可用作抗真菌剂及其生产方法等。一种由下式表示的化合物： 或其药学上可接受的盐，以及含有相同成分的抗真菌剂等。
• Method for producing kakeromycin and derivatives thereof
  申请人：OP BIO FACTORY CO., LTD.

  公开号：US10618876B2

  公开（公告）日：2020-04-14

  Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.

  本发明提供了一种通过化学合成生产具有抗真菌活性和细胞毒性并有望成为新型抗真菌剂或抗癌剂的卡克霉素及其衍生物的方法。一种由式（1）代表的化合物的生产方法： 其中 R 是任选取代的烃基或任选取代的杂环基；且 n 是 0 或 1，或其盐，包括将式（2）所代表的化合物进行以下步骤 其中 R 和 n 如上文所定义，或其盐，进行氧化反应。
• US9896457B2
  申请人：——

  公开号：US9896457B2

  公开（公告）日：2018-02-20