| 1374646-99-7

• CAS: 1374646-99-7
• 化学式: C₁₁H₁₈CuLiO₂
• 分子量: 252.75
• InChiKey: NVBUCYFOZMPHNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  以 氘代四氢呋喃 、 氘代苯 为溶剂， 生成
  参考文献：
  名称：

  Ligand Exchange in Mixed Organocuprate(I) π-Complexes

  摘要：

  pi-Complexes of mixed organocuprate(I) reagents with alpha,beta-unsaturated carbonyl compounds can undergo ligand exchange to give the corresponding homocuprate-olefin pi-complexes. The mechanism of this metathesis, which has profound implications for synthetic applications, involves a second order reaction of the Mixed cuprate with the mixed cuprate-olefin pi-complex.

  DOI：

  10.1021/om3006646
• 作为产物：
  描述：

  丁烯酮 、 copper(I) lithium 3-methoxy-3-methylbut-1-yn-1-ide methanide 以 氘代四氢呋喃 、 氘代苯 为溶剂， 生成
  参考文献：
  名称：

  Ligand Exchange in Mixed Organocuprate(I) π-Complexes

  摘要：

  pi-Complexes of mixed organocuprate(I) reagents with alpha,beta-unsaturated carbonyl compounds can undergo ligand exchange to give the corresponding homocuprate-olefin pi-complexes. The mechanism of this metathesis, which has profound implications for synthetic applications, involves a second order reaction of the Mixed cuprate with the mixed cuprate-olefin pi-complex.

  DOI：

  10.1021/om3006646

文献信息

• Minimization of Organocuprate Complexity through Self-Organization: Remarkable Orientation Effect in Mixed Cuprate π Complexes
  作者：Steven H. Bertz、Richard A. Hardin、Michael D. Murphy、Craig A. Ogle、Joshua D. Richter、Andy A. Thomas

  DOI：10.1002/anie.201107060

  日期：2012.3.12

  where to go: A powerful orientation effect has been observed in complexes of mixed organocuprates [RTRNTCuLi] and substrates with CC, CN, and CS double bonds (see scheme; Th=thienyl). The preferred geometry of the intermediate complex sets up the facile addition of RT to the double bond, rather than addition of the “dummy ligand”, RNT.

  他们“知道”去哪里：一个强大的取向效应在混合有机铜[R的复合物中观察到Ť ř NT CuLi]和底物使用C  C，C  N，和C  š双键（参见方案; TH =噻吩基）。中间配合物的优选几何形状建立了将R T容易地添加到双键中，而不是添加了“虚拟配体” R NT。