cis-ammine(4-aminomethyl-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum(II) | 479633-83-5

• 英文名称: cis-ammine(4-aminomethyl-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum(II)
• CAS: 479633-83-5
• 化学式: C₁₀H₂₄ClIN₃OPt
• 分子量: 559.758
• InChiKey: IERXSZHYECKMKY-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  cis-ammine(4-aminomethyl-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum(II) 、 potassium chloride 、 silver nitrate 以 水 为溶剂， 以58%的产率得到cis-ammine(4-aminomethyl-2,2,6,6-tetramethylpiperidin-1-oxyl)dichloroplatinum(II)
  参考文献：
  名称：

  摘要：

  The mixed-ligand complexes cis-Pt-11[R(CH2),NH2](NH3)X-2, where R = 2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl, X-2 = ClI or Cl-2, n = 1 or 2, and binuclear complexes trans-3,4-bis[cis-ammine (iodochloro or dichloro)platinum(II)amino]-2,2,6,6-tetramethylpiperidin-1-oxyls were synthesized. The reactivity of the aminonitroxide complexes toward DNA, the destabilizing effect of the adducts on DNA structure, and the distribution of the Pt adducts along the DNA duplex were studied. The platination activity of the complexes is affected by the natures of both the leaving ligands X and the carrying amino ligands. The decrease in the platination activity of the complexes with an increase in the amino ligand sizes is probably caused by steric hindrance. The complexes that effectively platinate isolated DNA and cause a moderate destabilizition of DNA duplex possess high antitumor activities.

  DOI：

  10.1023/a:1019686323902
• 作为产物：
  描述：

  sodium iodide 、 K{PtaCl3}*H2O 、 2,2,6,6-tetramethyl-4-aminomethylpiperidine-N-oxyl 以 水 为溶剂， 生成 cis-ammine(4-aminomethyl-2,2,6,6-tetramethylpiperidin-1-oxyl)iodochloroplatinum(II)
  参考文献：
  名称：

  摘要：

  The mixed-ligand complexes cis-Pt-11[R(CH2),NH2](NH3)X-2, where R = 2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl, X-2 = ClI or Cl-2, n = 1 or 2, and binuclear complexes trans-3,4-bis[cis-ammine (iodochloro or dichloro)platinum(II)amino]-2,2,6,6-tetramethylpiperidin-1-oxyls were synthesized. The reactivity of the aminonitroxide complexes toward DNA, the destabilizing effect of the adducts on DNA structure, and the distribution of the Pt adducts along the DNA duplex were studied. The platination activity of the complexes is affected by the natures of both the leaving ligands X and the carrying amino ligands. The decrease in the platination activity of the complexes with an increase in the amino ligand sizes is probably caused by steric hindrance. The complexes that effectively platinate isolated DNA and cause a moderate destabilizition of DNA duplex possess high antitumor activities.

  DOI：

  10.1023/a:1019686323902