4-(3-aza-bicyclo[3.2.2]non-3-yl)-2,2-diphenyl-butyronitrile | 17824-43-0

• 英文名称: 4-(3-aza-bicyclo[3.2.2]non-3-yl)-2,2-diphenyl-butyronitrile
• 英文别名: 2,2-Diphenyl-4-(3-azabicyclo[3.2.2]non-3-yl)butyronitrile；4-(3-azabicyclo[3.2.2]nonan-3-yl)-2,2-diphenylbutanenitrile
• CAS: 17824-43-0
• 化学式: C₂₄H₂₈N₂
• 分子量: 344.5
• InChiKey: FRNIUMXTWKRNOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(3-aza-bicyclo[3.2.2]non-3-yl)-2,2-diphenyl-butyronitrile 、 乙酸酐 生成 3-[3-(5-methyl-[1,3,4]oxadiazol-2-yl)-3,3-diphenyl-propyl]-3-aza-bicyclo[3.2.2]nonane
  参考文献：
  名称：

  3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a novel series of antidiarrheal agents

  摘要：

  A series of 4-amino-2,2-diarylbutyronitriles (3) prepared for testing as inhibitors of gastrointestinal propulsive activity did not show any enhancement over such existing agents as diphenoxylate and loperamide. However, conversion of the nitrile group to a 2-methyl-1,3,4-oxadiazol-5-yl function led to compounds 5g and 5j, statistically equipotent to diphenoxylate and loperamide in the mouse and showing a very low order of analgesic activity. Structural modifications determined that the best separation of antipropulsive and analgesic effects was obtained when the amino group was bicyclic and the oxadiazole ring had a 2-methyl substituent. The most potent compounds were and analogues of diphenoxylate and loperamide where the oxadiazole ring was present, but these compounds had marked analgesic activity.

  DOI：

  10.1021/jm00232a010

文献信息

• Nepeta plant named ‘Bokratune’
  申请人：Jan Kraan Kees

  公开号：USPP029556P2

  公开（公告）日：2018-07-31

  A new cultivar of Nepeta named ‘Bokratune’ that is characterized by its very compact plant habit with a plant height of about 35 cm, its flowers that are deep violet-blue in color, its flowers that are large in size relative to the overall plant size, and its good re-blooming response after dead-heading with new flowers produced in about 4 weeks.

  一种新的荆芥品种，名为“ Bokratune”，其特点是植株非常紧凑，高约35厘米，花朵呈深紫蓝色，相对于整个植株大小而言，花朵较大，死亡后具有良好的再次开花反应，约4周后会产生新花。
• USRE29556E
  申请人：——

  公开号：USRE29556E

  公开（公告）日：1978-02-28