2-Azido-1-(4-hydroxy-3-methoxyphenyl)ethanone | 1426148-10-8

• 英文名称: 2-Azido-1-(4-hydroxy-3-methoxyphenyl)ethanone
• CAS: 1426148-10-8
• 化学式: C₉H₉N₃O₃
• 分子量: 207.189
• InChiKey: HDSZSHKKALYOPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Azido-1-(4-hydroxy-3-methoxyphenyl)ethanone 在 potassium ethyl xanthogenate 作用下， 以 异丙醇 为溶剂， 反应 6.0h， 生成 (4-hydroxy-3-methoxyphenyl)(5-(4-hydroxy-3-methoxyphenyl)-1H-imidazol-2-yl)methanone 、 (4-hydroxy-3-methoxyphenyl)(4-(4-hydroxy-3-methoxyphenyl)-1H-imidazol-2-yl)methanone
  参考文献：
  名称：

  One-pot synthesis of disubstituted imidazole derivatives from α-azido ketones catalyzed by potassium ethylxanthate

  摘要：

  An efficient, novel procedure for the synthesis of new imidazole derivatives from alpha-azido ketones is described. This reaction proceeds via dimerization of aryl glyoxal imino generated from alpha-azido ketones in the presence of potassium ethylxanthate as a catalyst. A possible mechanism for the entire sequence is proposed. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.01.042