(FcCO)2NHbenzim | 913618-84-5

• 英文名称: (FcCO)2NHbenzim
• CAS: 913618-84-5
• 化学式: C₂₉H₂₃Fe₂N₃O₂
• 分子量: 557.215
• InChiKey: PWLLIQJAFXUTRX-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-氨基苯并咪唑 、 ferrocenoyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (FcCO)2NHbenzim
  参考文献：
  名称：

  二茂铁衍生物的电化学研究和潜在的抗癌活性

  摘要：

  摘要 合成了几种二茂铁衍生物（五个单核和两个双核），包括新的 N-（对氯苯基）-甲酰氨基二茂铁 (1)，并研究了它们的抗癌活性。其中带有苯并咪唑主链的 3 和 7 两种对 HeLa 细胞最有活性，IC50 值达到~5 μM，4 种带有联吡啶胺配体（~6 μM）。同样具有苯并咪唑骨架的复合物 6 显示出略高的值 (~11 μM)。循环伏安法研究表明，虽然非细胞毒性二茂铁衍生物 1、2 和 5 遵循基于二茂铁的氧化还原行为，但衍生物 3、4、6 和 7 表现出更复杂的机制。这些复杂的机制与更有效的细胞毒活性一致。穆斯堡尔光谱参数反映了非常小的取代基影响。

  DOI：

  10.1080/00958972.2016.1257125

文献信息

• Synthesis and ligand properties towards gold and silver of the ferrocenylamidobenzimidazole ligand
  作者：Maria José Calhorda、Paulo J. Costa、Paulo N. Martinho、M. Concepción Gimeno、Antonio Laguna、Susana Quintal、M. Dolores Villacampa

  DOI：10.1016/j.jorganchem.2006.06.025

  日期：2006.10

  The treatment of FcCOCl (Fc = (C5H5)Fe(C5H4)) With amino benzimidazole in 1: 1 or 2:1 ratio gives the ferrocenyl-amido derivatives FcCO(benzimNH(2)) or (FcCO)(2)(NHbenzim), respectively. The reactivity of FcCO(benzimNH(2)) with silver or gold complexes has been studied. The reaction with the basic gold compounds [Au(acac)(PPh3)] or [O(AuPPh3)(3)]ClO4 occurs with deprotonation of the NH2 group and coordination of one or three gold(phosphine) fragments. The treatment of this ligand with silver compounds, such as Ag(OTf) or [Ag(OTf)(PPh3)], gives the complexes of stoichiometry [Ag(OTf)L] or [Ag(OTf)(PPh3)]. The ligand FcCO(benzimNH(2)) and the complex [Ag(OTf)FcCO(benzimNH(2))}(PPh3)] have been characterized by X-ray diffraction studies. DFT calculations were performed on models of this dimeric silver complex and showed that dimerization is energetically favourable, because Ag(I) achieves a four coordination environment, despite some bonds being relatively weak. (c) 2006 Elsevier B.V. All rights reserved.